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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.11.000
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.700
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.631
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.564
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.506
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.493
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.484
3t8oATPRhodopsin kinase/0.483
2hog710Serine/threonine-protein kinase Chk12.7.11.10.480
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.478
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.475
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.472
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.471
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.471
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.466
4bbe3O4Tyrosine-protein kinase JAK2/0.466
4ii5ADPCyclin-dependent kinase 22.7.11.220.465
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.464
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.462
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.460
3c4zADPRhodopsin kinase/0.460
4aguD15Cyclin-dependent kinase-like 1/0.460
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.459
4fv9E71Mitogen-activated protein kinase 12.7.11.240.459
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.458
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.458
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.458
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.458
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.458
1xl2189Gag-Pol polyprotein3.4.23.160.456
1zrzBI1Protein kinase C iota type2.7.11.130.456
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.454
4j99ACPFibroblast growth factor receptor 2/0.454
4l9i8PRRhodopsin kinase/0.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.452
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.450
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.450
4gmy0X5Tyrosine-protein kinase JAK2/0.450
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.450
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.448
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.448
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2c4g514Cyclin-dependent kinase 22.7.11.220.447
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.447
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.446
5eg3ACPFibroblast growth factor receptor 2/0.445
2x6dX6DAurora kinase A2.7.11.10.444
3bqr4RBDeath-associated protein kinase 3/0.444
4hge15VTyrosine-protein kinase JAK2/0.443
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.443
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
2vu3LZECyclin-dependent kinase 22.7.11.220.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.441
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.441
2ckeIQUDeath-associated protein kinase 2/0.441
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.441
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.441
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.441
2pywADPMethylthioribose kinase2.7.1.1000.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.440
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440