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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kzl20DTankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kzl20DTankyrase-22.4.2.301.000
4l10A63Tankyrase-22.4.2.300.845
4l2f1V3Tankyrase-22.4.2.300.808
4l0v1V1Tankyrase-22.4.2.300.775
4l0s1UZTankyrase-22.4.2.300.764
4bu908CTankyrase-22.4.2.300.763
4but31FTankyrase-22.4.2.300.757
4buuF38Tankyrase-22.4.2.300.750
4bufF36Tankyrase-22.4.2.300.729
4hlf15ZTankyrase-22.4.2.300.724
4buiW2ETankyrase-22.4.2.300.706
4hlk431Tankyrase-22.4.2.300.694
5aku29FTankyrase-22.4.2.300.689
4bus32FTankyrase-22.4.2.300.663
4buxF35Tankyrase-22.4.2.300.658
4l0t1V0Tankyrase-22.4.2.300.657
4l341VGTankyrase-22.4.2.300.655
4l2g1V4Tankyrase-22.4.2.300.645
4hlm16STankyrase-22.4.2.300.642
4bueJQFTankyrase-22.4.2.300.641
4l0i1UWTankyrase-22.4.2.300.634
4iueAJ4Tankyrase-22.4.2.300.631
3kr8XAVTankyrase-22.4.2.300.629
4hl515WTankyrase-22.4.2.300.629
4avwG18Tankyrase-22.4.2.300.623
4hlg20BTankyrase-22.4.2.300.621
4hlh20DTankyrase-22.4.2.300.619
4bud29FTankyrase-22.4.2.300.614
4hkkAGITankyrase-22.4.2.300.614
4l321VFTankyrase-22.4.2.300.614
4l2k1V8Tankyrase-22.4.2.300.607
4hknLU2Tankyrase-22.4.2.300.604
4hmhF94Tankyrase-22.4.2.300.604
4l31F08Tankyrase-22.4.2.300.601
4j22AJ7Tankyrase-22.4.2.300.599
4l091URTankyrase-22.4.2.300.599
4buwF33Tankyrase-22.4.2.300.597
3p0pNNFTankyrase-22.4.2.300.594
4bs4A64Tankyrase-22.4.2.300.592
4kzuA73Tankyrase-22.4.2.300.592
4j21AJ6Tankyrase-22.4.2.300.580
4l33F70Tankyrase-22.4.2.300.573
4hkiFLNTankyrase-22.4.2.300.572
4buv16ITankyrase-22.4.2.300.560
4krs1SXTankyrase-12.4.2.300.560
4pnrG18Tankyrase-22.4.2.300.534
4bjbP34Tankyrase-22.4.2.300.516
4j3mAJ8Tankyrase-22.4.2.300.512
4msk2C8Tankyrase-12.4.2.300.508
4j3lAJ5Tankyrase-22.4.2.300.493
2j83BATUlilysin3.4.240.490
4pnmNU1Tankyrase-22.4.2.300.490
3tqcADPPantothenate kinase/0.487
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.479
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.470
4avuLDRTankyrase-22.4.2.300.465
1zdwFLVPrenyltransferase/0.464
1xk9P34Exotoxin A2.4.2.360.461
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.458
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.458
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.456
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.456
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
2xw7NDPDihydrofolate reductase/0.451
4tjy3GNTankyrase-22.4.2.300.451
2bf7HBIPteridine reductase 11.5.1.330.450
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.447
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.446
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.445
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.445
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.444
2vprTDCTetracycline repressor protein class H/0.443
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.442
2zb8IMNProstaglandin reductase 21.3.1.480.441
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.440
3u9y09LTankyrase-22.4.2.300.440
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.440