scPDB - Distribution of Binding site Similarity values of 4je5 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4je5	PLP	Aromatic/aminoadipate aminotransferase 1	2.6.1.39

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4je5	PLP	Aromatic/aminoadipate aminotransferase 1	2.6.1.39	1.000
4wlj	IK2	Kynurenine--oxoglutarate transaminase 1	2.6.1.7	0.518
3ele	PLP	Aminotransferase	/	0.506
4fl0	PLP	Aminotransferase ALD1, chloroplastic	2.6.1	0.495
4ge9	0L0	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.493
1asc	NPL	Aspartate aminotransferase	2.6.1.1	0.487
4emy	PLP	Aminotransferase class I and II	/	0.486
3hl0	NAD	Maleylacetate reductase	/	0.483
2g24	7IG	Renin	3.4.23.15	0.479
1aka	PLP	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.478
1cq6	PY4	Aspartate aminotransferase	2.6.1.1	0.476
3ei8	PL5	LL-diaminopimelate aminotransferase, chloroplastic	/	0.474
1x28	PGU	Aspartate aminotransferase	2.6.1.1	0.473
1u08	PLP	Methionine aminotransferase	/	0.471
3nub	UD0	UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase	2.6.1.98	0.471
4nhy	PD2	Prolyl 3-hydroxylase OGFOD1	1.14.11	0.470
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.468
4w5k	PLP	Aspartate aminotransferase, mitochondrial	/	0.467
3zc3	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.465
2zev	IPE	Geranylgeranyl pyrophosphate synthase	/	0.462
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.462
3fvu	IAC	Kynurenine--oxoglutarate transaminase 1	2.6.1.7	0.461
1akb	PPD	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.460
1cq8	PY6	Aspartate aminotransferase	2.6.1.1	0.459
3int	GDU	UDP-galactopyranose mutase	5.4.99.9	0.459
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.459
3frk	TQP	QdtB	/	0.458
1oj4	CDM	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	2.7.1.148	0.457
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.457
2iko	7IG	Renin	3.4.23.15	0.455
3fr5	I4A	Fatty acid-binding protein, adipocyte	/	0.455
1esm	COA	Pantothenate kinase	2.7.1.33	0.454
1nqv	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.454
2gyw	OBI	Acetylcholinesterase	3.1.1.7	0.454
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.454
4u14	0HK	Muscarinic acetylcholine receptor M3	/	0.454
3b05	FNR	Isopentenyl-diphosphate delta-isomerase	/	0.453
3dyq	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.453
1gg5	E09	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.452
2ea2	F77	Methionine aminopeptidase 2	/	0.452
2zrx	FMN	Isopentenyl-diphosphate delta-isomerase	/	0.452
4a31	2CB	Glycylpeptide N-tetradecanoyltransferase	/	0.452
3ccc	7AC	Dipeptidyl peptidase 4	/	0.451
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
3dyl	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
3jsi	WTC	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
3qpg	3QP	Aspartate aminotransferase	2.6.1.1	0.451
4flk	Y10	Methionine aminopeptidase 1	/	0.451
2a57	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.450
2vf3	GVS	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	/	0.450
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.450
4eb7	PLP	Cysteine desulfurase IscS 2	/	0.450
2gyu	HI6	Acetylcholinesterase	3.1.1.7	0.449
2zry	FNR	Isopentenyl-diphosphate delta-isomerase	/	0.449
3v2u	ATP	Protein GAL3	/	0.449
2ay9	5PV	Aromatic-amino-acid aminotransferase	2.6.1.57	0.448
2ha6	SCK	Acetylcholinesterase	3.1.1.7	0.448
2xvh	FAD	Putative flavin-containing monooxygenase	/	0.448
1cq7	PY5	Aspartate aminotransferase	2.6.1.1	0.447
1pqc	444	Oxysterols receptor LXR-beta	/	0.447
2ejz	SAH	Diphthine synthase	/	0.447
2g1n	1IG	Renin	3.4.23.15	0.447
2g1r	3IG	Renin	3.4.23.15	0.447
3hdq	GDU	UDP-galactopyranose mutase	/	0.447
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
4b65	NDP	L-ornithine N(5)-monooxygenase	/	0.447
1qpl	587	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.446
2ay3	MPP	Aromatic-amino-acid aminotransferase	2.6.1.57	0.446
3ufl	508	Beta-secretase 1	3.4.23.46	0.446
4mrm	2BY	Gamma-aminobutyric acid type B receptor subunit 1	/	0.446
4rkd	KET	Aminotransferase	/	0.446
2e9a	B28	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.445
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.445
2c20	NAD	UDP-glucose 4-epimerase	/	0.444
3e32	ED2	Protein farnesyltransferase subunit beta	2.5.1.58	0.444
3nyt	ULP	UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase	2.6.1.98	0.444
4usq	FAD	Pyridine nucleotide-disulfide oxidoreductase	/	0.444
1s4o	GDP	Glycolipid 2-alpha-mannosyltransferase	/	0.443
1toi	HCI	Aspartate aminotransferase	2.6.1.1	0.443
2ges	COK	Pantothenate kinase	2.7.1.33	0.443
2j3q	TFL	Acetylcholinesterase	3.1.1.7	0.443
3ziu	LSS	Leucyl-tRNA synthetase	/	0.443
4e90	7RG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
4mr7	2BV	Gamma-aminobutyric acid type B receptor subunit 1	/	0.443
4nv1	4TG	Formyl transferase	/	0.443
4mqt	2CU	Muscarinic acetylcholine receptor M2	/	0.443
2g1s	4IG	Renin	3.4.23.15	0.442
2qf2	GDP	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	4.1.1.32	0.442
2xiq	5AD	Methylmalonyl-CoA mutase, mitochondrial	/	0.442
4b67	NAP	L-ornithine N(5)-monooxygenase	/	0.442
4b7z	Q4Q	Acetylcholinesterase	3.1.1.7	0.442
4j7h	TRH	PCZA361.3	/	0.442
4jay	NAP	UDP-N-acetylenolpyruvoylglucosamine reductase	/	0.442
1n95	HFP	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	/	0.441
1n95	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.441
1q5m	NDP	Prostaglandin-E(2) 9-reductase	1.1.1.189	0.441
3h3q	H13	Collagen type IV alpha-3-binding protein	/	0.441
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.441
1kyx	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.440
1w76	GNT	Acetylcholinesterase	3.1.1.7	0.440
2a0w	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.440
3dr7	GPD	GDP-perosamine synthase	/	0.440
3k3e	PDB	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440
3qgi	33F	Genome polyprotein	2.7.7.48	0.440
3sfy	3FY	Uncharacterized protein	/	0.440
3uzx	AOM	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.440
4fse	0VA	Beta-secretase 1	3.4.23.46	0.440
4m2a	UPG	UDP-glucose pyrophosphorylase	/	0.440