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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4j56FADThioredoxin reductase 21.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4j56FADThioredoxin reductase 21.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.578
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.570
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.555
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.553
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.549
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.547
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.525
1gerFADGlutathione reductase1.8.1.70.519
1bzlFADTrypanothione reductase1.8.1.120.515
1febFADTrypanothione reductase1.8.1.120.509
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.506
4nevFADTrypanothione reductase/0.506
1zk7FADMercuric reductase1.16.1.10.500
2r9zFADGlutathione amide reductase/0.497
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.496
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.495
2v6oFADThioredoxin glutathione reductase/0.494
1grhFADGlutathione reductase, mitochondrial1.8.1.70.492
4jq9FADDihydrolipoyl dehydrogenase/0.490
1grgFADGlutathione reductase, mitochondrial1.8.1.70.487
1zx9FADMercuric reductase1.16.1.10.487
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.484
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.484
3grsFADGlutathione reductase, mitochondrial1.8.1.70.484
1greFADGlutathione reductase, mitochondrial1.8.1.70.480
2eq9FADDihydrolipoyl dehydrogenase/0.480
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.479
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.478
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.474
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.473
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.472
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.471
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.467
3ladFADDihydrolipoyl dehydrogenase/0.465
3urhFADDihydrolipoyl dehydrogenase/0.465
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.464
1geuFADGlutathione reductase1.8.1.70.461
2eq8FADDihydrolipoyl dehydrogenase/0.460
2hqmFADGlutathione reductase1.8.1.70.460
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.458
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.458
1yqzFADCoenzyme A disulfide reductase/0.457
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.457
4eqsFADCoenzyme A disulfide reductase/0.457
1graFADGlutathione reductase, mitochondrial1.8.1.70.455
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.454
3ic9FADPutative dihydrolipoamide dehydrogenase/0.452
4la1FADThioredoxin glutathione reductase/0.451
2yquFADDihydrolipoyl dehydrogenase/0.445
1onfFADGlutathione reductase1.8.1.70.444
1xdiFADNAD(P)H dehydrogenase (quinone)/0.443
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.443
1nhpFADNADH peroxidase1.11.1.10.441
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.440