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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h73NDPAldehyde dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4h73NDPAldehyde dehydrogenase/1.000
4nmjNAPAldehyde dehydrogenase/0.592
4nmkNAPAldehyde dehydrogenase/0.568
3iwkNADAminoaldehyde dehydrogenase/0.523
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.522
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.521
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/0.520
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.519
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.517
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.516
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.516
4wb9NAIRetinal dehydrogenase 11.2.1.360.510
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.500
1bxsNADRetinal dehydrogenase 11.2.1.360.495
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.495
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.495
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.491
4pz2NADAldehyde dehydrogenase 2-6/0.491
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.490
3iwjNADAminoaldehyde dehydrogenase/0.487
3hazNADBifunctional protein PutA/0.485
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.481
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.481
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.478
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.476
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.475
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.473
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.473
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.473
4x4lNAIRetinal dehydrogenase 11.2.1.360.471
4pxlNADAldehyde dehydrogenase3/0.469
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.467
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.467
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.467
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.460
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.460
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.456
4x2qNADRetinal dehydrogenase 21.2.1.360.455
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.454
4i3vNADAldehyde dehydrogenase (NAD+)/0.451
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.450
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.450
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.449
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.449
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.443
5eyuNADBetaine-aldehyde dehydrogenase/0.442
4f3xNADPutative aldehyde dehydrogenase/0.441
4itbNDPSuccinate-semialdehyde dehydrogenase/0.440