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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.35

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.351.000
2p5uNADUDP-glucose 4-epimerase/0.560
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.536
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.523
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.523
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.521
4lk3NADUDP-glucuronic acid decarboxylase 14.1.1.350.511
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.509
4yagNAIC alpha-dehydrogenase/0.502
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.499
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.496
4egbNADdTDP-glucose 4,6-dehydratase/0.496
1g1aNADdTDP-glucose 4,6-dehydratase/0.495
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.492
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.492
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.492
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.490
4yaiNAIC alpha-dehydrogenase/0.490
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.485
1kvrNADUDP-glucose 4-epimerase5.1.3.20.482
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.482
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.482
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.474
1i3lNADUDP-glucose 4-epimerase/0.473
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.472
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.471
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.471
5jlaNADPutative short-chain dehydrogenase/reductase/0.470
3toxNAPPutative oxidoreductase/0.468
1nahNADUDP-glucose 4-epimerase5.1.3.20.467
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.467
2c20NADUDP-glucose 4-epimerase/0.466
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.464
4fn4NADShort chain dehydrogenase/0.464
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.463
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.463
4esoNAPPutative oxidoreductase/0.461
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.458
3a1nNADNDP-sugar epimerase/0.457
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.457
3a4vNADNDP-sugar epimerase/0.455
1mg5NAIAlcohol dehydrogenase1.1.1.10.453
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.453
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.452
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.451
4xgiNADGlutamate dehydrogenase/0.451
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
1naiNADUDP-glucose 4-epimerase5.1.3.20.448
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.448
1g6kNADGlucose 1-dehydrogenase1.1.1.470.447
3ko8NADNAD-dependent epimerase/dehydratase/0.447
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.445
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.445
1z7eATPBifunctional polymyxin resistance protein ArnA/0.444
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.444
2jahNDPClavaldehyde dehydrogenase/0.443
3d3wNAPL-xylulose reductase1.1.1.100.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.443
4qecNAPElxO/0.443
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.443
1zemNADXylitol dehydrogenase/0.442
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.442
5idwNAPShort-chain dehydrogenase/reductase SDR/0.442
1pr9NAPL-xylulose reductase1.1.1.100.441
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.441
4b8zNAPGDP-L-fucose synthase1.1.1.2710.441
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.440
1sbyNADAlcohol dehydrogenase1.1.1.10.440
5lc1NADL-threonine 3-dehydrogenase/0.440