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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fv2EK5Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fv2EK5Mitogen-activated protein kinase 12.7.11.241.000
2ojj82AMitogen-activated protein kinase 12.7.11.240.561
4fv6E57Mitogen-activated protein kinase 12.7.11.240.535
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.529
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.521
4qnyANPMitogen activated protein kinase, putative/0.518
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.515
4gt3ATPMitogen-activated protein kinase 12.7.11.240.511
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.504
3c4xATPRhodopsin kinase/0.502
3i60E86Mitogen-activated protein kinase 12.7.11.240.498
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.497
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.496
4h3qANPMitogen-activated protein kinase 12.7.11.240.496
4aguD15Cyclin-dependent kinase-like 1/0.494
3c4wATPRhodopsin kinase/0.480
4s33ANPMitogen-activated protein kinase 12.7.11.240.480
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.476
4l9i8PRRhodopsin kinase/0.473
4nifANPMitogen-activated protein kinase 12.7.11.240.473
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.471
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.469
2j0lANPFocal adhesion kinase 12.7.10.20.468
3c4zADPRhodopsin kinase/0.468
4fv9E71Mitogen-activated protein kinase 12.7.11.240.468
2yaaATPDeath-associated protein kinase 2/0.467
3lltANPProtein serine/threonine kinase-1/0.463
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.462
1jklANPDeath-associated protein kinase 12.7.11.10.460
4eooATPCyclin-dependent kinase 22.7.11.220.460
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.459
4ic7ANPMitogen-activated protein kinase 72.7.11.240.459
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.458
1jkkANPDeath-associated protein kinase 12.7.11.10.456
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.456
3gu7ADPDeath-associated protein kinase 12.7.11.10.455
3qc9ADPRhodopsin kinase/0.455
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.455
2j0m4STFocal adhesion kinase 12.7.10.20.454
3orpAGSSerine/threonine protein kinase/0.453
5av3KMPDeath-associated protein kinase 12.7.11.10.453
2w4jADPDeath-associated protein kinase 12.7.11.10.452
3nieANPMitogen-activated protein kinase/0.451
4c3pACPAurora kinase A2.7.11.10.451
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.449
4s34ANPMitogen-activated protein kinase 12.7.11.240.448
5av2KMPDeath-associated protein kinase 12.7.11.10.448
3t8oATPRhodopsin kinase/0.447
1ig1ANPDeath-associated protein kinase 12.7.11.10.445
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.445
5dosATPAurora kinase A2.7.11.10.445
4j95ACPFibroblast growth factor receptor 2/0.442
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.440
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440