sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 1.000 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.526 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.521 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.515 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.495 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.482 | |
| 3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.477 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.472 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.467 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.464 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.461 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.459 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.458 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.458 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.457 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.457 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.453 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.451 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.450 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.449 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.449 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.448 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.447 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.446 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.446 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.443 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.443 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.442 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.442 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.441 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.441 | |
| 5doz | NDP | JamJ | / | 0.441 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 |