sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 1.000 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.609 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.594 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.575 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.529 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.527 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.520 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.514 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.509 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.506 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.505 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.504 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.503 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.498 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.495 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.491 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.490 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.489 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.488 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.485 | |
| 3ua1 | 08Y | Cytochrome P450 3A4 | / | 0.485 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.483 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.481 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.480 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.479 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.479 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.477 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.477 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.475 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.475 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.468 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.468 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.466 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.466 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.465 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.461 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.460 | |
| 4egn | TWO | Cytochrome P450 | / | 0.460 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.452 | |
| 4k9v | 6AW | Cytochrome P450 3A4 | / | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.448 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.448 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3cse | N22 | Uncharacterized protein | / | 0.445 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.442 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.441 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |