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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.11.000
3lltANPProtein serine/threonine kinase-1/0.549
2yaaATPDeath-associated protein kinase 2/0.541
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.534
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.528
3dfcANPDeath-associated protein kinase 12.7.11.10.499
2ijmADPFocal adhesion kinase 12.7.10.20.494
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.493
3c4xATPRhodopsin kinase/0.484
5dosATPAurora kinase A2.7.11.10.482
4j95ACPFibroblast growth factor receptor 2/0.480
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2j0lANPFocal adhesion kinase 12.7.10.20.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.469
5av2KMPDeath-associated protein kinase 12.7.11.10.469
3gu7ADPDeath-associated protein kinase 12.7.11.10.468
4l9i8PRRhodopsin kinase/0.467
3begANPSRSF protein kinase 12.7.11.10.466
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.466
4j99ACPFibroblast growth factor receptor 2/0.466
4ysjADPCalmodulin-like domain protein kinase/0.466
5av3KMPDeath-associated protein kinase 12.7.11.10.464
1jklANPDeath-associated protein kinase 12.7.11.10.463
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.461
4jboWPHAurora kinase A2.7.11.10.461
3i60E86Mitogen-activated protein kinase 12.7.11.240.460
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.460
3bu5ATPInsulin receptor2.7.10.10.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
4c3pACPAurora kinase A2.7.11.10.459
4qmlANPSerine/threonine-protein kinase 242.7.11.10.458
3kvxFMYMitogen-activated protein kinase 102.7.11.240.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.456
4qnyANPMitogen activated protein kinase, putative/0.455
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3c4zADPRhodopsin kinase/0.453
3t8oATPRhodopsin kinase/0.451
5cvfATPCasein kinase II subunit alpha2.7.11.10.451
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.449
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.445
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.445
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.444
3c4wATPRhodopsin kinase/0.443
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.441
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.441
4s33ANPMitogen-activated protein kinase 12.7.11.240.441
4aguD15Cyclin-dependent kinase-like 1/0.440