sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 1.000 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.553 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.523 | |
| 4at5 | MUJ | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.517 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.513 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.511 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.504 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.495 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.490 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.489 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.485 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.485 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.483 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.483 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.482 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.481 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.479 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.478 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.478 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.476 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.474 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.474 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.473 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.473 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.473 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.473 | |
| 3p9t | TCL | Repressor | / | 0.473 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.473 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.472 | |
| 1buc | FAD | Acyl-CoA dehydrogenase, short-chain specific | 1.3.8.1 | 0.471 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.471 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.471 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.468 | |
| 1syn | F89 | Thymidylate synthase | / | 0.468 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.468 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.468 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.468 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.467 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.467 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.466 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.466 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.466 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.466 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.466 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.466 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.466 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.461 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.461 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.461 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.461 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.461 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.461 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.460 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.460 | |
| 4dm8 | REA | Retinoic acid receptor beta | / | 0.460 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.459 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.459 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.459 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.459 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.459 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.457 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4jpc | 1M6 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.457 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.457 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.456 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.456 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.456 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.456 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.456 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.456 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.456 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.455 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.455 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.455 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.455 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.455 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.454 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.453 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.453 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.453 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.453 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.452 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.452 | |
| 4ybn | FAD | Flavin-nucleotide-binding protein | / | 0.452 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.452 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.452 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.452 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.451 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2jiz | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.451 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.451 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.451 | |
| 3up3 | XCA | aceDAF-12 | / | 0.451 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.451 | |
| 4b1f | KRH | Glutamate racemase | / | 0.451 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.451 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.450 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.450 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 3aba | FLI | Cytochrome P450 | / | 0.450 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.450 | |
| 3stx | BKA | Methylketone synthase I | / | 0.450 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.450 | |
| 4iah | 1DX | Alr2278 protein | / | 0.450 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.450 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.450 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.449 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.449 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.449 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.449 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.449 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.449 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.449 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.449 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.449 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.449 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.448 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.448 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 3d76 | NBB | Pheromone-binding protein ASP1 | / | 0.448 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3htj | ET | EbrA repressor | / | 0.448 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.448 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1sqb | AZO | Cytochrome b | / | 0.447 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.447 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.447 | |
| 3lu8 | IQX | Serum albumin | / | 0.447 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.447 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.447 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.446 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.446 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.446 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.446 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.446 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.446 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.446 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.445 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.445 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.445 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.445 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.445 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.445 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.445 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.445 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.444 | |
| 1e7a | PFL | Serum albumin | / | 0.444 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.444 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.444 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.444 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.444 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.443 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.443 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2mjp | ANP | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.443 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.443 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3l2k | PXC | EhpF | / | 0.443 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.443 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2vez | ACO | Glucosamine 6-phosphate acetyltransferase, putative | / | 0.442 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 3hqd | ANP | Kinesin-like protein KIF11 | / | 0.442 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.442 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.442 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.442 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.442 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.442 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.441 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.441 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.441 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 2wpw | ACO | Orf14 | / | 0.441 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3up0 | D7S | aceDAF-12 | / | 0.441 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.441 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.440 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.440 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2igx | A1T | Plasmepsin 2 | / | 0.440 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3h18 | PMS | Esterase/lipase | / | 0.440 | |
| 3qly | 55V | Uncharacterized protein | / | 0.440 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.440 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.440 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |