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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4afjSJJGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4afjSJJGlycogen synthase kinase-3 beta2.7.11.261.000
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.633
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.600
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.589
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.583
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.582
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.581
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.579
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.563
3du8553Glycogen synthase kinase-3 beta2.7.11.260.555
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.554
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.545
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.544
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.535
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.531
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.530
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.520
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.519
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.513
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.503
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.503
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.502
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.502
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.498
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.496
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.491
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.489
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.489
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.488
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.488
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.487
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.487
3zh8C58Protein kinase C iota type2.7.11.130.482
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.481
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.478
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.475
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.474
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.471
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.471
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.471
2cchATPCyclin-dependent kinase 22.7.11.220.470
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.470
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.469
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.468
4aguD15Cyclin-dependent kinase-like 1/0.468
2i0ePDSProtein kinase C beta type2.7.11.130.467
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.467
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.466
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.466
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.465
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.464
3be9P04Casein kinase II subunit alpha2.7.11.10.464
4bchT7ZCyclin-dependent kinase 92.7.11.220.464
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.463
4qo9627Serine/threonine-protein kinase 242.7.11.10.463
1pkdUCNCyclin-dependent kinase 22.7.11.220.462
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.461
3eb0DRKUncharacterized protein/0.461
3iw4LW4Protein kinase C alpha type2.7.11.130.461
4enhFVXCholesterol 24-hydroxylase/0.460
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
3gubGUBDeath-associated protein kinase 12.7.11.10.459
4jr3KJREpidermal growth factor receptor2.7.10.10.459
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.458
4gmy0X5Tyrosine-protein kinase JAK2/0.458
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.457
4j97ACPFibroblast growth factor receptor 2/0.457
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.457
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.455
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.454
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.454
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.454
1fvv107Cyclin-dependent kinase 22.7.11.220.453
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.453
4wsqKSAAP2-associated protein kinase 12.7.11.10.453
3oom507Activin receptor type-12.7.11.300.452
3zep1NXTyrosine-protein kinase JAK32.7.10.20.452
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
2hog710Serine/threonine-protein kinase Chk12.7.11.10.451
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.451
2w05FRTCyclin-dependent kinase 22.7.11.220.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
2qo9ANPEphrin type-A receptor 32.7.10.10.450
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.450
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.449
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.449
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.449
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.449
2iw84SPCyclin-dependent kinase 22.7.11.220.448
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
1y0s331Peroxisome proliferator-activated receptor delta/0.447
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4dgnLU2Casein kinase II subunit alpha2.7.11.10.446
4dymIYZActivin receptor type-12.7.11.300.446
4jrvKJVEpidermal growth factor receptor2.7.10.10.446
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.445
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.445
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.444
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.444
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
2vd5BI8Myotonin-protein kinase2.7.11.10.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
4hvh19RTyrosine-protein kinase JAK32.7.10.20.443
4jqeANPCasein kinase II subunit alpha2.7.11.10.443
4o0wADNAurora kinase A2.7.11.10.443
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.443
4qmySTUSerine/threonine-protein kinase 242.7.11.10.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.442
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.442
3oroAGSSerine/threonine protein kinase/0.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.441
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.441
2jedLG8Protein kinase C theta type2.7.11.130.441
2wihP48Cyclin-dependent kinase 22.7.11.220.441
4bcnT9NCyclin-dependent kinase 22.7.11.220.441
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.441
4jq8KJ8Epidermal growth factor receptor2.7.10.10.441
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.441
1h1r6CPCyclin-dependent kinase 22.7.11.220.440
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.440
1zys199Serine/threonine-protein kinase Chk12.7.11.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
4qmzB49Serine/threonine-protein kinase 242.7.11.10.440