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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rix923Luciferin 4-monooxygenase1.13.12.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rix923Luciferin 4-monooxygenase1.13.12.71.000
3iesM24Luciferin 4-monooxygenase1.13.12.70.629
2d1sSLULuciferin 4-monooxygenase1.13.12.70.515
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.488
1hb1OCVIsopenicillin N synthase1.21.3.10.487
2vcmM11Isopenicillin N synthase1.21.3.10.487
1blzACVIsopenicillin N synthase1.21.3.10.478
1bk0ACVIsopenicillin N synthase1.21.3.10.475
1oc1ASVIsopenicillin N synthase1.21.3.10.470
1w06W05Isopenicillin N synthase1.21.3.10.469
2y6fM9FIsopenicillin N synthase1.21.3.10.468
4bb3KKAIsopenicillin N synthase1.21.3.10.468
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.468
2y60M8FIsopenicillin N synthase1.21.3.10.467
3tscNADUncharacterized protein/0.467
2tpsTPSThiamine-phosphate synthase/0.466
1qjfACSIsopenicillin N synthase1.21.3.10.463
2wo7ASVIsopenicillin N synthase1.21.3.10.463
2ztsADPUncharacterized protein/0.463
2jb4A14Isopenicillin N synthase1.21.3.10.462
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
3zoiM2WIsopenicillin N synthase1.21.3.10.462
2dhfDZFDihydrofolate reductase1.5.1.30.461
2vbpVB1Isopenicillin N synthase1.21.3.10.461
4z0pNDPNAD-dependent dehydrogenase/0.461
1qiqACCIsopenicillin N synthase1.21.3.10.460
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.460
2r0pK2CPutative FAD-monooxygenase/0.460
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.459
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.459
2vcwZZAHematopoietic prostaglandin D synthase/0.458
5dbfNDPIridoid synthase1.3.1.990.458
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.457
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.457
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.457
5idwNAPShort-chain dehydrogenase/reductase SDR/0.456
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3bi6396Wee1-like protein kinase2.7.10.20.455
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.455
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
1ra3NAPDihydrofolate reductase1.5.1.30.453
5ab6CAANonspecific lipid-transfer protein, putative/0.453
1hb3SCVIsopenicillin N synthase1.21.3.10.452
3bg7FADPyranose 2-oxidase/0.452
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.452
2zsdCOAPantothenate kinase2.7.1.330.451
3bi5FADPolyamine oxidase FMS1/0.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.450
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.450
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.450
5g53NECAdenosine receptor A2a/0.450
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3kybFADUDP-galactopyranose mutase5.4.99.90.449
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.449
2dw4FADLysine-specific histone demethylase 1A10.448
2givACOHistone acetyltransferase KAT8/0.448
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.448
2qocANPEphrin type-A receptor 32.7.10.10.448
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
3slkNDPPolyketide synthase extender module 2/0.448
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.448
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.448
1kzjCB3Thymidylate synthase/0.447
1uzwCDHIsopenicillin N synthase1.21.3.10.447
1w4zNAPPutative ketoacyl reductase1.3.10.447
3zkyWT4Isopenicillin N synthase1.21.3.10.447
4bfsZVSPantothenate kinase2.7.1.330.447
4f4qFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.447
4j5rA1RO-acetyl-ADP-ribose deacetylase 13.5.10.447
4rvgTYDD-mycarose 3-C-methyltransferase/0.447
5dozNDPJamJ/0.447
5jlaNADPutative short-chain dehydrogenase/reductase/0.447
2idkC2FGlycine N-methyltransferase2.1.1.200.446
2iviACWIsopenicillin N synthase1.21.3.10.446
3l0lHC3Nuclear receptor ROR-gamma/0.446
3s55NADPutative short-chain dehydrogenase/reductase/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
1pqc444Oxysterols receptor LXR-beta/0.445
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3vt8YI3Vitamin D3 receptor/0.445
5emhNAPIridoid synthase1.3.1.990.445
1oaaNAPSepiapterin reductase1.1.1.1530.444
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.444
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.444
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.444
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.444
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.444
3hkyIX6Genome polyprotein2.7.7.480.444
4dpi0N1Beta-secretase 13.4.23.460.444
4fflADPUncharacterized protein/0.444
5dbgNADIridoid synthase1.3.1.990.444
5f54TMPSingle-stranded-DNA-specific exonuclease/0.444
2c29NAPDihydroflavonol 4-reductase/0.443
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.443
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.443
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.443
3a1l2CCCytochrome P450/0.443
5dp2NAPCurF/0.443
2vbdV10Isopenicillin N synthase1.21.3.10.442
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.442
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.441
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1kvrNADUDP-glucose 4-epimerase5.1.3.20.441
2fhnBNIAvidin-related protein 4/5/0.441
2rgoFADAlpha-Glycerophosphate Oxidase/0.441
2yy7NADL-threonine dehydrogenase/0.441
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.441
4bfvZVVPantothenate kinase2.7.1.330.441
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.441
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.440
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.440
2vdgNDPAldose reductase1.1.1.210.440
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.440
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
3q43D66M1 family aminopeptidase3.4.110.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.440
5dcyNAPIridoid synthase1.3.1.990.440