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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3r6pA8SAbscisic acid receptor PYL10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3r6pA8SAbscisic acid receptor PYL10/1.000
3oquA8SAbscisic acid receptor PYL9/0.534
4dscA8SAbscisic acid receptor PYL3/0.534
3njoP2MAbscisic acid receptor PYR1/0.532
3nefPYVAbscisic acid receptor PYL1/0.517
3negPYVAbscisic acid receptor PYL1/0.517
3w9rA8SAbscisic acid receptor PYL9/0.507
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.498
3ujlA8SAbscisic acid receptor PYL2/0.492
2vn0TDZCytochrome P450 2C8/0.491
3nmpPYVAbscisic acid receptor PYL2/0.489
3ns2PYVAbscisic acid receptor PYL2/0.487
4oicA8SBet v I allergen-like/0.486
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.482
3njoPYVAbscisic acid receptor PYR1/0.481
4jdaA9SAbscisic acid receptor PYL3/0.480
4lg5A1OAbscisic acid receptor PYL2/0.480
3nr4PYVAbscisic acid receptor PYL2/0.478
4la7A1OAbscisic acid receptor PYL2/0.478
4ds8A8SAbscisic acid receptor PYL3/0.473
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.472
3kdiA8SAbscisic acid receptor PYL2/0.472
1og5SWFCytochrome P450 2C9/0.471
3nj0PYVAbscisic acid receptor PYL2/0.471
4dsbA8SAbscisic acid receptor PYL3/0.467
1l2jETCEstrogen receptor beta/0.466
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.466
3eej53RUncharacterized protein/0.464
4lgaA2OAbscisic acid receptor PYL2/0.463
1rk3VDXVitamin D3 receptor/0.462
1ysx4EBSerum albumin/0.462
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.462
3k3kA8SAbscisic acid receptor PYR1/0.461
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
5br4NADLactaldehyde reductase1.1.1.770.461
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.460
1phgMYTCamphor 5-monooxygenase1.14.15.10.459
3nmnPYVAbscisic acid receptor PYL1/0.458
3zvuA8SAbscisic acid receptor PYR1/0.458
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2zb45OPProstaglandin reductase 21.3.1.480.457
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.457
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1txiTX5Vitamin D3 receptor/0.456
3qly55VUncharacterized protein/0.456
3vt7VDXVitamin D3 receptor/0.456
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4g1z0VPVitamin D3 receptor A/0.456
4iteTEYVitamin D3 receptor/0.456
1dkfBMSRetinoic acid receptor alpha/0.455
3kb3A8SAbscisic acid receptor PYL2/0.455
4fhi0S4Vitamin D3 receptor A/0.455
1iyzNDPProbable quinone oxidoreductase/0.454
1rkgVD1Vitamin D3 receptor/0.454
1rkhVD2Vitamin D3 receptor/0.454
2hb8MVDVitamin D3 receptor/0.454
2hw2RFPRifampin ADP-ribosyl transferase/0.454
3lu8IQXSerum albumin/0.454
3vt9YI4Vitamin D3 receptor/0.454
1db1VDXVitamin D3 receptor/0.453
2qblCAMCamphor 5-monooxygenase1.14.15.10.453
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.453
1klkPMDDihydrofolate reductase1.5.1.30.452
3kdjA8SAbscisic acid receptor PYL1/0.452
3qn1A8SAbscisic acid receptor PYR1/0.452
4cd2FOLDihydrofolate reductase1.5.1.30.452
3vrwYS5Vitamin D3 receptor/0.451
4ea13RXDehydrosqualene synthase/0.451
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.451
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.450
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.450
1s3vTQDDihydrofolate reductase1.5.1.30.449
2hasC3OVitamin D3 receptor/0.449
3abaFLICytochrome P450/0.449
3vt65YIVitamin D3 receptor/0.449
4o701QKBromodomain-containing protein 4/0.449
2fziDH3Dihydrofolate reductase1.5.1.30.448
2hcdBIVVitamin D3 receptor A/0.448
3gkjHC3Niemann-Pick C1 protein/0.448
3u8hBHPPhospholipase A2, membrane associated/0.448
3zsh469Mitogen-activated protein kinase 14/0.448
4l8u9AZSerum albumin/0.448
4mxeACON-acetyltransferase ESCO12.3.10.448
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.447
1d2sDHTSex hormone-binding globulin/0.446
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.446
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
2po7CHDFerrochelatase, mitochondrial4.99.1.10.446
3c3dFO12-phospho-L-lactate transferase/0.446
1ie8KH1Vitamin D3 receptor/0.445
1rx8FOLDihydrofolate reductase1.5.1.30.445
1s19MC9Vitamin D3 receptor/0.445
2hb7O1CVitamin D3 receptor/0.445
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.445
3drcMTXDihydrofolate reductase1.5.1.30.445
3l0lHC3Nuclear receptor ROR-gamma/0.445
3w5rLOAVitamin D3 receptor/0.445
4b7dQLECytochrome P450 monooxygenase PikC/0.445
5dq8FLFTranscriptional enhancer factor TEF-4/0.445
1jipKTN6-deoxyerythronolide B hydroxylase/0.444
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.444
2jn3JN3Fatty acid-binding protein, liver/0.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3w0hW12Vitamin D3 receptor/0.444
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4h9506UDihydrofolate reductase1.5.1.30.444
4h9753SDihydrofolate reductase1.5.1.30.444
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3t8xT8XT-cell surface glycoprotein CD1b/0.443
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.443
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.443
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ia7BIVVitamin D3 receptor A/0.443
4itfTFYVitamin D3 receptor/0.443
1ie9VDXVitamin D3 receptor/0.442
2vf0F89Thymidylate synthase/0.442
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.442
3vtcTK3Vitamin D3 receptor/0.442
3w5p4OAVitamin D3 receptor/0.442
4ruoBIVVitamin D3 receptor A/0.442
1tdrMTXDihydrofolate reductase1.5.1.30.441
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3w0aDS5Vitamin D3 receptor/0.441
4bcqTJFCyclin-dependent kinase 22.7.11.220.441
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4q0a4OAVitamin D3 receptor A/0.441
4z34ON7Lysophosphatidic acid receptor 1/0.441
2hamC33Vitamin D3 receptor/0.440
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.440
2vcmM11Isopenicillin N synthase1.21.3.10.440
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.440
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.440
4jlj1NMDeoxycytidine kinase2.7.1.740.440
4l4bCAMCamphor 5-monooxygenase1.14.15.10.440
4l9kEHFSerum albumin/0.440