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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qrwNDPPutative ketoacyl reductase1.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qrwNDPPutative ketoacyl reductase1.3.11.000
1w4zNAPPutative ketoacyl reductase1.3.10.624
1x7hNDPPutative ketoacyl reductase1.3.10.606
4dc1NDPPutative ketoacyl reductase1.3.10.594
1x7gNAPPutative ketoacyl reductase1.3.10.589
3sjuNDPKeto reductase/0.579
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.554
4hwkNAPSepiapterin reductase1.1.1.1530.540
1ae1NAPTropinone reductase 1/0.533
3p19NDPPutative blue fluorescent protein/0.528
3gy0NAPNAD(P)-dependent oxidoreductase/0.527
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.525
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.524
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.522
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.522
1pr9NAPL-xylulose reductase1.1.1.100.519
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.513
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.508
3f1kNAPUncharacterized oxidoreductase YciK10.507
1n5dNDPCarbonyl reductase [NADPH] 1/0.506
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.506
4qecNAPElxO/0.505
1ipeNDPTropinone reductase 21.1.1.2360.504
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.504
4j7xNAPSepiapterin reductase1.1.1.1530.503
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.502
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.501
1wntNAPL-xylulose reductase1.1.1.100.501
2bd0NAPSepiapterin reductase/0.501
3toxNAPPutative oxidoreductase/0.501
2yutNAPPutative short-chain oxidoreductase/0.500
4j7uNAPSepiapterin reductase1.1.1.1530.497
1xkqNDPUncharacterized protein/0.496
3u4cNDPNADPH-dependent reductase BacG/0.496
5jlaNADPutative short-chain dehydrogenase/reductase/0.496
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.495
3l77NJPShort-chain alcohol dehydrogenase/0.495
3tn7NJPShort-chain alcohol dehydrogenase/0.495
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.495
1snyNAPLD36273p/0.494
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.493
1xg5NAPDehydrogenase/reductase SDR family member 11/0.492
3w8fNAD3-hydroxybutyrate dehydrogenase/0.492
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.489
3lqfNADGalactitol dehydrogenase/0.489
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.486
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.486
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.485
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.484
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.482
5idwNAPShort-chain dehydrogenase/reductase SDR/0.481
4bmvNAPShort-chain dehydrogenase/0.478
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.477
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.475
1oaaNAPSepiapterin reductase1.1.1.1530.472
3ai2NDPNADPH-sorbose reductase/0.472
3w8dNAD3-hydroxybutyrate dehydrogenase/0.471
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.470
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.469
2dteNAIGlucose 1-dehydrogenase related protein/0.468
2wdzNADGalactitol dehydrogenase/0.468
3ak4NADNADH-dependent quinuclidinone reductase/0.468
4gh5NADShort-chain dehydrogenase/reductase SDR/0.468
1geeNADGlucose 1-dehydrogenase1.1.1.470.467
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.466
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
3ai3NDPNADPH-sorbose reductase/0.466
1g6kNADGlucose 1-dehydrogenase1.1.1.470.465
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.464
2wsbNADGalactitol dehydrogenase/0.464
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.462
3w8eNAD3-hydroxybutyrate dehydrogenase/0.462
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.462
1b15NAEAlcohol dehydrogenase1.1.1.10.461
3uceNDPDehydrogenase/0.461
4esoNAPPutative oxidoreductase/0.461
4yaiNAIC alpha-dehydrogenase/0.461
3wdsNADNADH-dependent quinuclidinone reductase/0.460
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.459
1gcoNADGlucose 1-dehydrogenase1.1.1.470.458
1b16NAQAlcohol dehydrogenase1.1.1.10.457
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.457
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.456
1rwbNADGlucose 1-dehydrogenase1.1.1.470.455
3rj9NADAlcohol dehydrogenase1.1.1.10.455
3vdqNAD3-hydroxybutyrate dehydrogenase/0.455
5lc1NADL-threonine 3-dehydrogenase/0.455
3uxyNADShort-chain dehydrogenase/reductase SDR/0.453
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.452
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.452
4qedNAPElxO/0.452
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.451
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.451
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.450
1sbyNADAlcohol dehydrogenase1.1.1.10.448
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.446
5emhNAPIridoid synthase1.3.1.990.446
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.445
4fn4NADShort chain dehydrogenase/0.445
4impNDPPolyketide synthase extender modules 3-4/0.445
1b14NADAlcohol dehydrogenase1.1.1.10.444
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.444
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.444
2jahNDPClavaldehyde dehydrogenase/0.442