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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3oroAGSSerine/threonine protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3oroAGSSerine/threonine protein kinase/1.000
3ortAGSSerine/threonine protein kinase/0.546
3ormAGSSerine/threonine protein kinase/0.542
3oriAGSSerine/threonine protein kinase/0.513
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.507
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.489
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.483
3orpAGSSerine/threonine protein kinase/0.482
3c4zADPRhodopsin kinase/0.479
4lfiGNPCasein kinase II subunit alpha2.7.11.10.479
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.476
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
3eljGS7Mitogen-activated protein kinase 82.7.11.240.474
3orkAGSSerine/threonine protein kinase/0.471
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.470
2pvnP63Casein kinase II subunit alpha2.7.11.10.469
3nieANPMitogen-activated protein kinase/0.469
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.468
4h3qANPMitogen-activated protein kinase 12.7.11.240.468
3lltANPProtein serine/threonine kinase-1/0.467
4ix6ADPUncharacterized protein/0.467
4hge15VTyrosine-protein kinase JAK2/0.466
4ysjADPCalmodulin-like domain protein kinase/0.464
1m2pHNACasein kinase II subunit alpha2.7.11.10.463
5cnoANPEpidermal growth factor receptor2.7.10.10.463
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.462
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3cgfJNFMitogen-activated protein kinase 102.7.11.240.458
2pvhP19Casein kinase II subunit alpha2.7.11.10.456
3zh8C58Protein kinase C iota type2.7.11.130.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.455
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.455
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
4deeADPAurora kinase A2.7.11.10.454
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.454
4nifANPMitogen-activated protein kinase 12.7.11.240.452
2ijmADPFocal adhesion kinase 12.7.10.20.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.449
1dawANPCasein kinase II subunit alpha2.7.11.10.448
1jklANPDeath-associated protein kinase 12.7.11.10.448
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.448
4axfANPInositol-pentakisphosphate 2-kinase2.7.1.1580.448
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3kvxFMYMitogen-activated protein kinase 102.7.11.240.446
5av2KMPDeath-associated protein kinase 12.7.11.10.446
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.445
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.445
4j95ACPFibroblast growth factor receptor 2/0.445
4jr7GNPCasein kinase II subunit alpha2.7.11.10.445
4qnyANPMitogen activated protein kinase, putative/0.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.444
2ds11CDCyclin-dependent kinase 22.7.11.220.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.443
1pmn984Mitogen-activated protein kinase 102.7.11.240.442
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
4ux9ANPMitogen-activated protein kinase 82.7.11.240.442
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
3be9P04Casein kinase II subunit alpha2.7.11.10.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.440
5cvfATPCasein kinase II subunit alpha2.7.11.10.440