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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.537
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.520
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.515
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.484
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.482
1osvCHCBile acid receptor/0.479
1y0s331Peroxisome proliferator-activated receptor delta/0.478
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.477
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.477
4b7dQLECytochrome P450 monooxygenase PikC/0.471
1ouk084Mitogen-activated protein kinase 14/0.470
4mihFADPyranose 2-oxidase1.1.3.100.469
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.468
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.468
2uxoTACHTH-type transcriptional regulator TtgR/0.466
3p3zP3ZPutative cytochrome P450/0.466
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
3slkNDPPolyketide synthase extender module 2/0.465
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.464
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.463
1ot7CHCBile acid receptor/0.462
3vtbTKAVitamin D3 receptor/0.461
1ppjANYCytochrome b/0.460
4jlj1NMDeoxycytidine kinase2.7.1.740.460
3lqfNADGalactitol dehydrogenase/0.459
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.458
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.458
3poz03PEpidermal growth factor receptor2.7.10.10.458
3vtdTKDVitamin D3 receptor/0.458
3vt8YI3Vitamin D3 receptor/0.457
3vtcTK3Vitamin D3 receptor/0.457
3w33W19Epidermal growth factor receptor2.7.10.10.457
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.457
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.456
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4b7sQLECytochrome P450 monooxygenase PikC/0.456
1jioDEB6-deoxyerythronolide B hydroxylase/0.455
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
2q59240Peroxisome proliferator-activated receptor gamma/0.455
3tdaPN0Cytochrome P450 2D6/0.455
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
2ylrFADPhenylacetone monooxygenase1.14.13.920.454
3k4nFADPyranose 2-oxidase/0.454
4y8wSTRSteroid 21-hydroxylase/0.454
2ydwWSHBromodomain-containing protein 2/0.453
3gobHXXDdmC/0.453
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.453
4g73NAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.453
4kip1R9Mitogen-activated protein kinase 14/0.453
2po7CHDFerrochelatase, mitochondrial4.99.1.10.452
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.452
4xiwAZMCarbonic anhydrase, alpha type/0.452
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.451
3vt3VDXVitamin D3 receptor/0.451
1s19MC9Vitamin D3 receptor/0.450
1bwsNDPGDP-L-fucose synthase/0.449
3cbsR12Cellular retinoic acid-binding protein 2/0.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3w0yDS4Vitamin D3 receptor/0.449
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4rujVDXVitamin D3 receptor A/0.449
2c6hPXICytochrome P450 monooxygenase PikC/0.448
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3l0lHC3Nuclear receptor ROR-gamma/0.448
3vt5YI2Vitamin D3 receptor/0.448
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.448
4xguADPPutative pachytene checkpoint protein 2/0.448
1bygSTUTyrosine-protein kinase CSK/0.447
3pe2E1BCasein kinase II subunit alpha2.7.11.10.447
3vt45YIVitamin D3 receptor/0.447
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.446
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.446
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.446
3w0aDS5Vitamin D3 receptor/0.446
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4xxvNAD3-isopropylmalate dehydrogenase/0.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4iji99TGlutathione S-transferase-like protein YibF/0.445
4v12POGMaoC like domain protein/0.445
1q4xG24Thyroid hormone receptor beta/0.444
2ftoCB3Thymidylate synthase/0.444
2vzmNRBCytochrome P450 monooxygenase PikC/0.444
3kytHC2Nuclear receptor ROR-gamma/0.444
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2c3qGTXGlutathione S-transferase theta-12.5.1.180.443
2hc4VDXVitamin D3 receptor A/0.443
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.443
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3fl4FL4Mitogen-activated protein kinase 14/0.443
3stv3HOMethylketone synthase I/0.443
3vrwYS5Vitamin D3 receptor/0.443
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2d29FADAcyl-CoA dehydrogenase/0.442
3b6zCO7Enoyl reductase LovC10.442
3gggNADPrephenate dehydrogenase/0.442
3lkiATPFructokinase/0.442
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.442
4nieNBHNuclear receptor ROR-gamma/0.442
4r81FMNPredicted NADH dehydrogenase/0.442
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.441
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.441
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3gqvNAPEnoyl reductase LovC10.441
4jx1CAMCamphor 5-monooxygenase1.14.15.10.441
4nh82LCHeat shock protein HSP 90-alpha/0.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
1jipKTN6-deoxyerythronolide B hydroxylase/0.440
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2x9dITCTetracycline repressor protein class D/0.440
3w0c6DSVitamin D3 receptor/0.440
4l8u9AZSerum albumin/0.440
4ryvZEAProtein LlR18A/0.440