scPDB - Distribution of Binding site Similarity values of 3gyf entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3gyf	51P	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3gyf	51P	Dihydrofolate reductase	1.5.1.3	1.000
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.629
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.619
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.612
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.607
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.606
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.599
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.598
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.593
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.592
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.588
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.584
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.583
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.577
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.575
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.568
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.565
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.564
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.564
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.563
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.559
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.557
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.547
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.543
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.541
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.538
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.534
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.530
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.527
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.522
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.520
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.519
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.515
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.513
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.510
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.510
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.509
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.509
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.505
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.502
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.502
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.501
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.499
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.493
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.491
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.491
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.488
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.485
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.476
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.475
3c72	CX1	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.473
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.473
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.472
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.470
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.470
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.470
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
3qly	55V	Uncharacterized protein	/	0.469
3cse	N22	Uncharacterized protein	/	0.468
3qlx	QLR	Uncharacterized protein	/	0.468
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.467
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.467
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.467
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.466
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.465
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.465
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.463
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.463
3v94	WYQ	Phosphodiesterase	/	0.461
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.460
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.460
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.460
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.460
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.460
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.459
2c9d	PHR	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.459
3qlz	QLZ	Uncharacterized protein	/	0.459
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.458
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.458
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.457
3qm4	PN0	Cytochrome P450 2D6	/	0.457
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.456
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.456
1q0z	AKA	Aclacinomycin methylesterase RdmC	3.1.1.95	0.456
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.456
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.456
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.455
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.455
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.454
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.453
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.453
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.453
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.452
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.452
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.452
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.452
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.452
3hxe	BD8	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.452
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3hu2	AGS	Transitional endoplasmic reticulum ATPase	3.6.4.6	0.451
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.451
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.451
4g2l	0WL	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
1pq6	965	Oxysterols receptor LXR-beta	/	0.450
1upw	444	Oxysterols receptor LXR-beta	/	0.450
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.450
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.449
4a95	9MT	Glycylpeptide N-tetradecanoyltransferase	/	0.449
1y2k	7DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.447
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.447
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.446
4g1n	NZT	Pyruvate kinase PKM	2.7.1.40	0.446
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.445
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.445
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.444
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.443
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.443
3ufl	508	Beta-secretase 1	3.4.23.46	0.443
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3hxd	BD7	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.442
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.442
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.441
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
1kce	CB3	Thymidylate synthase	/	0.440
1pq9	44B	Oxysterols receptor LXR-beta	/	0.440
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.440
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.440
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.440