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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gusN11Glutathione S-transferase P2.5.1.18

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gusN11Glutathione S-transferase P2.5.1.181.000
3ie3N11Glutathione S-transferase P2.5.1.180.719
3csjCBLGlutathione S-transferase P2.5.1.180.674
13gsSASGlutathione S-transferase P2.5.1.180.665
1aqxGTDGlutathione S-transferase P2.5.1.180.627
1gtiGTBGlutathione S-transferase P 12.5.1.180.627
4pgtGBXGlutathione S-transferase P2.5.1.180.621
1aqv0HGGlutathione S-transferase P2.5.1.180.619
20gsCBDGlutathione S-transferase P2.5.1.180.618
1pgtGTXGlutathione S-transferase P2.5.1.180.613
3pgtGBXGlutathione S-transferase P2.5.1.180.613
17gsGTXGlutathione S-transferase P2.5.1.180.612
2pgtGPRGlutathione S-transferase P2.5.1.180.606
2oa7GTXGlutathione S-transferase P 12.5.1.180.603
12gs0HHGlutathione S-transferase P2.5.1.180.597
2oadGTBGlutathione S-transferase P 12.5.1.180.593
9gssGTXGlutathione S-transferase P2.5.1.180.593
3n9jEAAGlutathione S-transferase P2.5.1.180.579
2j9hGTXGlutathione S-transferase P2.5.1.180.570
2glrGTXGlutathione S-transferase P 12.5.1.180.569
3o76GTBGlutathione S-transferase P 12.5.1.180.543
2oacGTBGlutathione S-transferase P 12.5.1.180.537
1tu8GTXGlutathione S-transferase 22.5.1.180.535
2a2sGSNGlutathione S-transferase P2.5.1.180.524
2po3T4K4-dehydrase/0.497
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.485
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.485
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.481
4ipw1G7Mycocyclosin synthase1.14.21.90.481
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.480
3l6jZ90Alr2278 protein/0.480
4bfzZVZPantothenate kinase2.7.1.330.475
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.474
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.469
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.468
4b4vL34Bifunctional protein FolD/0.467
4bfxZVXPantothenate kinase2.7.1.330.466
2e94364Geranylgeranyl pyrophosphate synthase/0.465
3bk2U5PRibonuclease J/0.465
4iae1DXAlr2278 protein/0.465
1tg56454-hydroxyphenylpyruvate dioxygenase1.13.11.270.464
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.463
4jlm1NNDeoxycytidine kinase2.7.1.740.463
1xddAAYIntegrin alpha-L/0.462
2vd0D27Hematopoietic prostaglandin D synthase/0.460
4n3r2GUTankyrase-12.4.2.300.460
4nieNBHNuclear receptor ROR-gamma/0.459
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.457
4jln18VDeoxycytidine kinase2.7.1.740.455
1gssLEEGlutathione S-transferase P2.5.1.180.454
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.454
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.454
4iah1DXAlr2278 protein/0.453
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1jdzFMBPurine nucleoside phosphorylase/0.452
2ylrNAPPhenylacetone monooxygenase1.14.13.920.452
3iocA5DPantothenate synthetase6.3.2.10.452
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.452
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3qgf46FGenome polyprotein2.7.7.480.451
3rsv3RSBeta-secretase 13.4.23.460.451
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.451
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.450
3dgqEAAGlutathione S-transferase P2.5.1.180.450
4isk1JYThymidylate synthase/0.450
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.449
4b4w9L9Bifunctional protein FolD/0.449
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.448
1pqc444Oxysterols receptor LXR-beta/0.448
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.448
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.448
1uhhCZPAequorin-2/0.447
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.447
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.446
4jazSTLPeroxisome proliferator-activated receptor gamma/0.446
1q23FUAChloramphenicol acetyltransferase2.3.1.280.445
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3rtnRTNBeta-secretase 13.4.23.460.445
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.445
1sm4FADFerredoxin--NADP reductase/0.444
1x1bSAHC-20 methyltransferase/0.444
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.444
4b63FADL-ornithine N(5)-monooxygenase/0.444
4bfuZVUPantothenate kinase2.7.1.330.444
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.443
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.443
3ivcFG4Pantothenate synthetase6.3.2.10.443
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.443
2ifaFMNUncharacterized protein/0.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.442
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
4q36CO8Uncharacterized protein/0.442
1esmCOAPantothenate kinase2.7.1.330.441
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.441
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.441
4a83DXCMajor pollen allergen Bet v 1-A/0.441
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.441
4jqh1MFAlr2278 protein/0.441
4n1fCZHObelin/0.441
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
1x1cSAHC-20 methyltransferase/0.440
2wzySQXSoluble acetylcholine receptor/0.440
3ihgVAKAklavinone 12-hydroxylase RdmE/0.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440