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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ghsLDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ghsLDTAldose reductase1.1.1.211.000
3ghrLDTAldose reductase1.1.1.210.910
3ghtLDTAldose reductase1.1.1.210.857
2i17LDTAldose reductase1.1.1.210.818
3ghuLDTAldose reductase1.1.1.210.795
3ld5LDTAldose reductase1.1.1.210.747
1us0LDTAldose reductase1.1.1.210.723
2fz8ZSTAldose reductase1.1.1.210.723
2i16LDTAldose reductase1.1.1.210.716
2hvoZSTAldose reductase1.1.1.210.714
2pdiZSTAldose reductase1.1.1.210.698
2qxwLDTAldose reductase1.1.1.210.694
3g5eQ74Aldose reductase1.1.1.210.690
2duxZSTAldose reductase1.1.1.210.674
2iki388Aldose reductase1.1.1.210.660
3mb9ZSTAldose reductase1.1.1.210.651
2pdlTOLAldose reductase1.1.1.210.648
1z3n3NAAldose reductase1.1.1.210.644
2duzZSTAldose reductase1.1.1.210.639
4gca2X9Aldose reductase1.1.1.210.631
2pdp393Aldose reductase1.1.1.210.629
2dv0ZSTAldose reductase1.1.1.210.627
2hv5ZSTAldose reductase1.1.1.210.627
2pzn393Aldose reductase1.1.1.210.626
3m64393Aldose reductase1.1.1.210.623
2pdg47DAldose reductase1.1.1.210.621
2pdmZSTAldose reductase1.1.1.210.614
1pwlBFIAldose reductase1.1.1.210.611
2pdh47DAldose reductase1.1.1.210.608
3t423T4Aldose reductase1.1.1.210.607
2pdxZSTAldose reductase1.1.1.210.606
1ieiZESAldose reductase1.1.1.210.604
3lenZSTAldose reductase1.1.1.210.603
2hvnZSTAldose reductase1.1.1.210.592
3lz5LDTAldose reductase1.1.1.210.592
2pdyFIDAldose reductase1.1.1.210.588
3m0iZSTAldose reductase1.1.1.210.588
2pdn47DAldose reductase1.1.1.210.586
2pdq47DAldose reductase1.1.1.210.581
3mc5393Aldose reductase1.1.1.210.579
2pdfZSTAldose reductase1.1.1.210.578
2pdbZSTAldose reductase1.1.1.210.577
1z8962PAldose reductase1.1.1.210.573
2pdu393Aldose reductase1.1.1.210.570
4yu153NAldose reductase1.1.1.210.568
1t40ID5Aldose reductase1.1.1.210.567
1frbZSTAldose reductase-related protein 2/0.563
1zuaTOLAldo-keto reductase family 1 member B101.1.10.562
2pdc393Aldose reductase1.1.1.210.562
2inzOHPAldose reductase1.1.1.210.560
2iqdLPAAldose reductase1.1.1.210.559
2fz9ZSTAldose reductase1.1.1.210.557
1t41ID5Aldose reductase1.1.1.210.556
2pdj393Aldose reductase1.1.1.210.556
2pd5ZSTAldose reductase1.1.1.210.548
2fzdTOLAldose reductase1.1.1.210.547
2ikhLITAldose reductase1.1.1.210.544
3lqlLDTAldose reductase1.1.1.210.543
2ikj393Aldose reductase1.1.1.210.541
3m4h388Aldose reductase1.1.1.210.534
2pdwFIDAldose reductase1.1.1.210.532
2f2kTGGAldose reductase1.1.1.210.526
3lboLDTAldose reductase1.1.1.210.519
1el3I84Aldose reductase1.1.1.210.518
2is72CLAldose reductase1.1.1.210.513
4ga8SBIAldo-keto reductase family 1 member B101.1.10.493
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.489
5liu388Aldo-keto reductase family 1 member B101.1.10.488
1ah3TOLAldose reductase1.1.1.210.486
3s3gTLTAldose reductase1.1.1.210.486
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.479
3v35NTIAldose reductase1.1.1.210.477
2fzbTOLAldose reductase1.1.1.210.475
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.474
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.473
2aovC2MHistamine N-methyltransferase2.1.1.80.471
3p2vDOYAldose reductase1.1.1.210.471
2xupTZ5Acetylcholinesterase3.1.1.70.470
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.470
2f3815MAldo-keto reductase family 1 member C3/0.469
4u163C0Muscarinic acetylcholine receptor M3/0.468
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.467
1lnmDTXBilin-binding protein/0.466
1odcA8BAcetylcholinesterase3.1.1.70.464
2aot2PMHistamine N-methyltransferase2.1.1.80.463
2nvcITAAldose reductase1.1.1.210.463
2pdkSBIAldose reductase1.1.1.210.463
3r8hZOMAldo-keto reductase family 1 member C3/0.463
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.462
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.462
1x8lOXRRetinol dehydratase/0.462
4wevSUZAldo-keto reductase family 1 member B101.1.10.462
3f3y4OABile salt sulfotransferase2.8.2.140.461
4dbs0HVAldo-keto reductase family 1 member C3/0.460
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.460
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.460
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.459
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.459
1ry0PG2Aldo-keto reductase family 1 member C3/0.458
2cbqTH2Neocarzinostatin/0.458
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.458
1xf0ASDAldo-keto reductase family 1 member C3/0.457
4li81XQTankyrase-12.4.2.300.456
2cekN8TAcetylcholinesterase3.1.1.70.455
2agtFIDAldose reductase1.1.1.210.454
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.454
1lkeDOGBilin-binding protein/0.453
4jq4IMNAldo-keto reductase family 1 member C2/0.453
1ah0SBIAldose reductase1.1.1.210.452
2ckmAA7Acetylcholinesterase3.1.1.70.452
2ea4F79Methionine aminopeptidase 2/0.452
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.452
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.451
2ct8MSPMethionine--tRNA ligase6.1.1.100.450
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.450
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.450
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.450
5c1gGDUHisto-blood group ABO system transferase/0.450
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.449
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.449
1q23FUAChloramphenicol acetyltransferase2.3.1.280.448
1yw7A41Methionine aminopeptidase 2/0.448
2xujTZ5Acetylcholinesterase3.1.1.70.447
1ihiIU5Aldo-keto reductase family 1 member C2/0.446
1r5gAO1Methionine aminopeptidase 2/0.446
1zgbA1EAcetylcholinesterase3.1.1.70.446
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.446
4dbw511Aldo-keto reductase family 1 member C3/0.446
1ut6A8NAcetylcholinesterase3.1.1.70.445
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
4kmzFOLFolate receptor beta/0.445
4m0f1YKAcetylcholinesterase3.1.1.70.445
4xo7ASDAldo-keto reductase family 1 member C2/0.445
1s36CEIObelin/0.444
4b65NDPL-ornithine N(5)-monooxygenase/0.444
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.444
4xba5GPAprataxin-like protein30.444
5stdUNNScytalone dehydratase4.2.1.940.444
1h35R01Squalene--hopene cyclase4.2.1.1290.443
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.443
1yw9A84Methionine aminopeptidase 2/0.443
3h3r14HCollagen type IV alpha-3-binding protein/0.443
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
1ry8RUTAldo-keto reductase family 1 member C3/0.442
2cmfF11Acetylcholinesterase3.1.1.70.442
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4u140HKMuscarinic acetylcholine receptor M3/0.442
2aclL05Oxysterols receptor LXR-alpha/0.441
3gf4UPGUDP-galactopyranose mutase5.4.99.90.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.441
1q83TZ5Acetylcholinesterase3.1.1.70.440
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2xuiTZ5Acetylcholinesterase3.1.1.70.440
4bfxZVXPantothenate kinase2.7.1.330.440