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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cwj321Genome polyprotein2.7.7.48

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cwj321Genome polyprotein2.7.7.481.000
3cdeN3HGenome polyprotein2.7.7.480.720
4ih71ERGenome polyprotein2.7.7.480.670
3h98B5PGenome polyprotein2.7.7.480.659
3d5m4MSGenome polyprotein2.7.7.480.657
3bsa1PDGenome polyprotein2.7.7.480.643
3u4o08EGenome polyprotein2.7.7.480.640
4mk728OGenome polyprotein2.7.7.480.640
2fvc888Polyprotein/0.633
3tyvHI3Genome polyprotein2.7.7.480.618
3uph0C1Genome polyprotein2.7.7.480.617
3h5sH5SGenome polyprotein2.7.7.480.614
3h5uH5UGenome polyprotein2.7.7.480.612
3e51N35Genome polyprotein2.7.7.480.610
4iz02BIGenome polyprotein2.7.7.480.610
3gynB42Genome polyprotein2.7.7.480.609
3golXNDGenome polyprotein2.7.7.480.608
4ih61EPGenome polyprotein2.7.7.480.602
3co93MSGenome polyprotein2.7.7.480.599
2gc8885Polyprotein/0.597
1z4uPH9Polyprotein/0.596
3h59H59Genome polyprotein2.7.7.480.592
3d28B34Genome polyprotein2.7.7.480.591
3upi0C2Genome polyprotein2.7.7.480.590
3ska053Genome polyprotein2.7.7.480.585
3gnwXNCGenome polyprotein2.7.7.480.581
3h2lYAKGenome polyprotein2.7.7.480.576
4mk828QGenome polyprotein2.7.7.480.576
3ske054Genome polyprotein2.7.7.480.575
2yoj8Y6Genome polyprotein2.7.7.480.569
3cvkN34Genome polyprotein2.7.7.480.554
3gnvXNZGenome polyprotein2.7.7.480.549
1yvfPH7Polyprotein/0.547
3hkwIX6Genome polyprotein2.7.7.480.521
4eaw0NQGenome polyprotein2.7.7.480.513
2qe5617Polyprotein/0.491
4jayNAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.470
2f3rG5PGuanylate kinase2.7.4.80.467
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.467
1xddAAYIntegrin alpha-L/0.462
4jb1NAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.460
2yxuATPPyridoxal kinase2.7.1.350.459
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.456
2ok7FADFerredoxin--NADP reductase, apicoplast/0.453
3v2uATPProtein GAL3/0.453
2wzwFMNNitroreductase NfnB/0.452
3rfaSAMDual-specificity RNA methyltransferase RlmN/0.452
4j0v1H7Beta-secretase 13.4.23.460.452
4blrUTPNTPase P4/0.450
2bn4NAPNADPH--cytochrome P450 reductase/0.448
4xguADPPutative pachytene checkpoint protein 2/0.448
4u8iFDAUDP-galactopyranose mutase/0.447
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.445
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.444
3fktSIIBeta-secretase 13.4.23.460.444
1u1gBBBUridine phosphorylase2.4.2.30.442
1joaFADNADH peroxidase1.11.1.10.441