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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3clyACPFibroblast growth factor receptor 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3clyACPFibroblast growth factor receptor 2/1.000
4k33ACPFibroblast growth factor receptor 32.7.10.10.539
4zseANPEpidermal growth factor receptor2.7.10.10.500
4j95ACPFibroblast growth factor receptor 2/0.499
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.491
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.483
4bn1ADPAurora kinase A2.7.11.10.483
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4oavACP2-5A-dependent ribonuclease3.1.260.479
5cnnANPEpidermal growth factor receptor2.7.10.10.479
5drdATPAurora kinase A2.7.11.10.477
5cnoANPEpidermal growth factor receptor2.7.10.10.476
5e92ANPTGF-beta receptor type-22.7.11.300.473
2rc3NADCBS domain/0.470
4oauADP2-5A-dependent ribonuclease3.1.260.470
4fryNADPutative signal-transduction protein with CBS domains/0.466
5eg3ACPFibroblast growth factor receptor 2/0.464
3hmm855TGF-beta receptor type-12.7.11.300.463
3poz03PEpidermal growth factor receptor2.7.10.10.462
4ryvZEAProtein LlR18A/0.462
3frqERYErythromycin resistance repressor protein/0.461
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
2y3rTRKTamL/0.460
5dt3ATPAurora kinase A2.7.11.10.460
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.459
3tqhNDPQuinone oxidoreductase/0.459
3w32W32Epidermal growth factor receptor2.7.10.10.459
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.459
1xddAAYIntegrin alpha-L/0.457
3gxlQIGTGF-beta receptor type-12.7.11.300.457
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
5jlaNADPutative short-chain dehydrogenase/reductase/0.455
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.454
1u54ACPActivated CDC42 kinase 1/0.454
4bwxAGSPAB-dependent poly(A)-specific ribonuclease subunit pan3/0.454
5dnrATPAurora kinase A2.7.11.10.454
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.453
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.453
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3d8bADPFidgetin-like protein 13.6.40.453
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.452
1ie4T44Transthyretin/0.452
1ol5ADPAurora kinase A2.7.11.10.452
1u4dDBQActivated CDC42 kinase 1/0.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.452
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.451
2y3rTIRTamL/0.451
3zc3NAPFerredoxin--NADP reductase1.18.1.20.451
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.451
2y4gTIRTamL/0.450
2znnS44Peroxisome proliferator-activated receptor alpha/0.450
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.450
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
2v7a627Tyrosine-protein kinase ABL12.7.10.20.448
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.447
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.446
3uoyNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.446
5e8ySTUTGF-beta receptor type-22.7.11.300.446
1wc1TATAdenylate cyclase/0.445
2nnhREACytochrome P450 2C8/0.445
3keuATPPyridoxal kinase2.7.1.350.445
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.445
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.445
4ki8ADP60 kDa chaperonin/0.445
1xkkFMMEpidermal growth factor receptor2.7.10.10.444
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.443
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.443
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.443
4u03GTPCyclic GMP-AMP synthase/0.443
1fm9570Peroxisome proliferator-activated receptor gamma/0.442
1ir3ANPInsulin receptor2.7.10.10.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ol7ADPAurora kinase A2.7.11.10.442
1qjfACSIsopenicillin N synthase1.21.3.10.442
2ijmATPFocal adhesion kinase 12.7.10.20.442
4h6rFDAProline dehydrogenase/0.442
1lrlUPGUDP-glucose 4-epimerase5.1.3.20.441
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.440
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.440
3sz0FADSulfide-quinone reductase/0.440
3t14FADSulfide-quinone reductase/0.440
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.440