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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3c4xATPRhodopsin kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3c4xATPRhodopsin kinase/1.000
3c4zADPRhodopsin kinase/0.611
3c4wATPRhodopsin kinase/0.604
3qc9ADPRhodopsin kinase/0.593
3t8oATPRhodopsin kinase/0.546
2j0lANPFocal adhesion kinase 12.7.10.20.523
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.517
4l9i8PRRhodopsin kinase/0.517
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.508
4qmlANPSerine/threonine-protein kinase 242.7.11.10.504
4deeADPAurora kinase A2.7.11.10.503
4c3pACPAurora kinase A2.7.11.10.501
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.499
4qnyANPMitogen activated protein kinase, putative/0.496
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.494
5dnrATPAurora kinase A2.7.11.10.479
3i60E86Mitogen-activated protein kinase 12.7.11.240.476
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.474
4ic7ANPMitogen-activated protein kinase 72.7.11.240.474
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.469
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.467
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.467
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.466
2yaaATPDeath-associated protein kinase 2/0.465
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4fv6E57Mitogen-activated protein kinase 12.7.11.240.463
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.460
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
4ysjADPCalmodulin-like domain protein kinase/0.458
2ijmATPFocal adhesion kinase 12.7.10.20.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.456
4i3zADPCyclin-dependent kinase 22.7.11.220.456
3lltANPProtein serine/threonine kinase-1/0.454
4jboWPHAurora kinase A2.7.11.10.454
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.453
2j0m4STFocal adhesion kinase 12.7.10.20.452
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.450
4aguD15Cyclin-dependent kinase-like 1/0.449
4qo9627Serine/threonine-protein kinase 242.7.11.10.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
5dosATPAurora kinase A2.7.11.10.449
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.448
2hog710Serine/threonine-protein kinase Chk12.7.11.10.446
4j95ACPFibroblast growth factor receptor 2/0.446
5l8lADPAurora kinase A2.7.11.10.446
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.442
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.442
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.441
2ijmADPFocal adhesion kinase 12.7.10.20.440