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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yy7NADL-threonine dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2yy7NADL-threonine dehydrogenase/1.000
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.584
5lc1NADL-threonine 3-dehydrogenase/0.573
3a1nNADNDP-sugar epimerase/0.542
3a4vNADNDP-sugar epimerase/0.530
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.518
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.512
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.511
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.509
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.508
4fn4NADShort chain dehydrogenase/0.507
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.503
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.499
4j7uNAPSepiapterin reductase1.1.1.1530.495
5jlaNADPutative short-chain dehydrogenase/reductase/0.493
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.492
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.491
2dteNAIGlucose 1-dehydrogenase related protein/0.490
4gh5NADShort-chain dehydrogenase/reductase SDR/0.490
4j7xNAPSepiapterin reductase1.1.1.1530.489
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.488
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.486
3ak4NADNADH-dependent quinuclidinone reductase/0.486
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.485
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.485
1pr9NAPL-xylulose reductase1.1.1.100.485
1ipeNDPTropinone reductase 21.1.1.2360.484
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.482
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.482
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.481
3gy0NAPNAD(P)-dependent oxidoreductase/0.481
3wdsNADNADH-dependent quinuclidinone reductase/0.481
1wntNAPL-xylulose reductase1.1.1.100.479
3d3wNAPL-xylulose reductase1.1.1.100.479
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.478
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.478
1ae1NAPTropinone reductase 1/0.475
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.475
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.474
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.473
4hwkNAPSepiapterin reductase1.1.1.1530.473
2wsbNADGalactitol dehydrogenase/0.472
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.472
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
1n5dNDPCarbonyl reductase [NADPH] 1/0.471
1w4zNAPPutative ketoacyl reductase1.3.10.471
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.470
1oaaNAPSepiapterin reductase1.1.1.1530.469
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.469
4dc1NDPPutative ketoacyl reductase1.3.10.469
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.469
5jydNADShort chain dehydrogenase/0.469
2bd0NAPSepiapterin reductase/0.468
3uxyNADShort-chain dehydrogenase/reductase SDR/0.468
1rwbNADGlucose 1-dehydrogenase1.1.1.470.466
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.465
1iy8NADLevodione reductase/0.465
3rj5NADAlcohol dehydrogenase1.1.1.10.465
4yaiNAIC alpha-dehydrogenase/0.465
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.464
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.464
3ajrNADNDP-sugar epimerase/0.464
3p19NDPPutative blue fluorescent protein/0.464
3sjuNDPKeto reductase/0.464
1mg5NAIAlcohol dehydrogenase1.1.1.10.463
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.463
1snyNAPLD36273p/0.463
3rj9NADAlcohol dehydrogenase1.1.1.10.463
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.462
4qecNAPElxO/0.462
2wdzNADGalactitol dehydrogenase/0.461
3s55NADPutative short-chain dehydrogenase/reductase/0.461
4b8wNAPGDP-L-fucose synthase1.1.1.2710.461
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.461
3qrwNDPPutative ketoacyl reductase1.3.10.460
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.460
2yutNAPPutative short-chain oxidoreductase/0.459
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.459
4yagNAIC alpha-dehydrogenase/0.459
3wmxNADNAD dependent epimerase/dehydratase/0.456
4b8zNAPGDP-L-fucose synthase1.1.1.2710.455
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.454
1b16NAQAlcohol dehydrogenase1.1.1.10.453
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.453
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.453
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.453
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.452
3lqfNADGalactitol dehydrogenase/0.451
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.451
1z7eATPBifunctional polymyxin resistance protein ArnA/0.450
3tn7NJPShort-chain alcohol dehydrogenase/0.450
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.450
2jahNDPClavaldehyde dehydrogenase/0.449
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.449
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.449
5idwNAPShort-chain dehydrogenase/reductase SDR/0.449
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
4bmvNAPShort-chain dehydrogenase/0.448
3w8eNAD3-hydroxybutyrate dehydrogenase/0.447
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
1rkxNADCDP-D-glucose-4,6-dehydratase/0.446
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.446
3f1kNAPUncharacterized oxidoreductase YciK10.446
1kvrNADUDP-glucose 4-epimerase5.1.3.20.445
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.445
4idgNADPutative UDP-glucose 4-epimerase/0.445
5ig2NADShort-chain dehydrogenase/reductase SDR/0.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.444
3sx2NADUncharacterized protein/0.443
3tscNADUncharacterized protein/0.443
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.442
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.442
1zemNADXylitol dehydrogenase/0.441
3ai3NDPNADPH-sorbose reductase/0.441
4nbwNADShort-chain dehydrogenase/reductase SDR/0.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3toxNAPPutative oxidoreductase/0.440