sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2yk2 | YJW | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.652 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.644 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.643 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.639 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.628 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.626 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.626 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.624 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.621 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.616 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.610 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.609 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.603 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.601 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.591 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.576 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.554 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.545 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.539 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.475 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.472 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.460 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.459 | |
| 1qy8 | RDI | Endoplasmin | / | 0.458 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.457 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.451 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.447 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.445 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.444 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.444 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.443 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.441 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.440 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.440 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.440 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 |