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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yaaATPDeath-associated protein kinase 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2yaaATPDeath-associated protein kinase 2/1.000
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.538
3lltANPProtein serine/threonine kinase-1/0.530
1jklANPDeath-associated protein kinase 12.7.11.10.523
5dosATPAurora kinase A2.7.11.10.509
3gu7ADPDeath-associated protein kinase 12.7.11.10.507
4qnyANPMitogen activated protein kinase, putative/0.492
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.492
3dfcANPDeath-associated protein kinase 12.7.11.10.490
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
5cvfATPCasein kinase II subunit alpha2.7.11.10.488
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.487
1ig1ANPDeath-associated protein kinase 12.7.11.10.480
4ysjADPCalmodulin-like domain protein kinase/0.480
1jkkANPDeath-associated protein kinase 12.7.11.10.479
5av3KMPDeath-associated protein kinase 12.7.11.10.479
4fv6E57Mitogen-activated protein kinase 12.7.11.240.478
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.477
5av2KMPDeath-associated protein kinase 12.7.11.10.476
2w4jADPDeath-associated protein kinase 12.7.11.10.475
2ijmADPFocal adhesion kinase 12.7.10.20.465
3i60E86Mitogen-activated protein kinase 12.7.11.240.460
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.458
4c3pACPAurora kinase A2.7.11.10.458
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.456
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.454
2j0lANPFocal adhesion kinase 12.7.10.20.452
1pjkANPCasein kinase II subunit alpha2.7.11.10.451
3c4xATPRhodopsin kinase/0.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.451
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.449
4j99ACPFibroblast growth factor receptor 2/0.447
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.446
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.446
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
4anmWULCasein kinase II subunit alpha2.7.11.10.444
3bu5ATPInsulin receptor2.7.10.10.443
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3begANPSRSF protein kinase 12.7.11.10.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440