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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xc5OYJCoagulation factor X3.4.21.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xc5OYJCoagulation factor X3.4.21.61.000
4bttVYRCoagulation factor X3.4.21.60.623
2xbxRR8Coagulation factor X3.4.21.60.570
2bdyUNBProthrombin3.4.21.50.484
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.476
1zgv501Prothrombin3.4.21.50.474
1d9i00PProthrombin3.4.21.50.465
2zhf49UProthrombin3.4.21.50.464
1zgi382Prothrombin3.4.21.50.463
3gwfFADCyclohexanone monooxygenase/0.461
4nieNBHNuclear receptor ROR-gamma/0.460
2zfr46UProthrombin3.4.21.50.458
3c1kT15Prothrombin3.4.21.50.458
2v3oI26Prothrombin3.4.21.50.457
2v3hI25Prothrombin3.4.21.50.456
1mueCDDProthrombin3.4.21.50.455
1rneC60Renin3.4.23.150.455
2znk31UProthrombin3.4.21.50.455
1d4pBPPProthrombin3.4.21.50.454
1lf2R37Plasmepsin-23.4.23.390.454
4arbC57Acetylcholinesterase3.1.1.70.454
3g5hYTTMycocyclosin synthase1.14.21.90.452
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.452
3udn09BBeta-secretase 13.4.23.460.451
1d3dBZTProthrombin3.4.21.50.450
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.450
1cf3FADGlucose oxidase1.1.3.40.448
3l5lFMNXenobiotic reductase/0.448
3q9bB3NAcetylpolyamine amidohydrolase/0.448
2ftoCB3Thymidylate synthase/0.447
3dux64UProthrombin3.4.21.50.447
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.447
1fmlRTLRetinol dehydratase/0.446
2xby63CCoagulation factor X3.4.21.60.445
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.445
3udj092Beta-secretase 13.4.23.460.445
2v16C47Renin3.4.23.150.444
2zhe13UProthrombin3.4.21.50.444
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.443
3oadLPORenin3.4.23.150.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
1pd9CO4Dihydrofolate reductase1.5.1.30.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3ensENSCoagulation factor X3.4.21.60.441
4gu5FADCryptochrome-1/0.441
4uthFMNXenobiotic reductase/0.441
5jscFADPutative acyl-CoA dehydrogenase/0.441
1c4uIH1Prothrombin3.4.21.50.440
2zda32UProthrombin3.4.21.50.440
3k4nFADPyranose 2-oxidase/0.440