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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wbaFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wbaFADTrypanothione reductase1.8.1.121.000
1bzlFADTrypanothione reductase1.8.1.120.610
2hqmFADGlutathione reductase1.8.1.70.586
1fecFADTrypanothione reductase1.8.1.120.583
4nevFADTrypanothione reductase/0.581
1gerFADGlutathione reductase1.8.1.70.578
1gxfFADTrypanothione reductase1.8.1.120.577
1febFADTrypanothione reductase1.8.1.120.575
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.573
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.572
2jk6FADTrypanothione reductase/0.568
4la1FADThioredoxin glutathione reductase/0.565
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.555
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.552
3grsFADGlutathione reductase, mitochondrial1.8.1.70.552
4dnaFADProbable glutathione reductase/0.552
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.549
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.545
1grgFADGlutathione reductase, mitochondrial1.8.1.70.544
4j56FADThioredoxin reductase 21.8.1.90.543
1tytFADTrypanothione reductase1.8.1.120.541
1typFADTrypanothione reductase1.8.1.120.533
1greFADGlutathione reductase, mitochondrial1.8.1.70.531
1feaFADTrypanothione reductase1.8.1.120.530
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.518
2r9zFADGlutathione amide reductase/0.508
2wp5FADTrypanothione reductase/0.508
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.508
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.508
2v6oFADThioredoxin glutathione reductase/0.504
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.503
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.500
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.493
4j57FADThioredoxin reductase 21.8.1.90.490
2eq8FADDihydrolipoyl dehydrogenase/0.489
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.488
2yquFADDihydrolipoyl dehydrogenase/0.483
1geuFADGlutathione reductase1.8.1.70.479
2eq9FADDihydrolipoyl dehydrogenase/0.478
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.478
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.477
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.469
1zk7FADMercuric reductase1.16.1.10.468
3nt6FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.467
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
2eq6FADDihydrolipoyl dehydrogenase/0.462
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.462
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.461
2w0hFADTrypanothione reductase/0.460
3ic9FADPutative dihydrolipoamide dehydrogenase/0.458
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.456
1nhsFADNADH peroxidase1.11.1.10.455
2wowFADTrypanothione reductase/0.455
3ladFADDihydrolipoyl dehydrogenase/0.455
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.454
4eqwFADCoenzyme A disulfide reductase/0.453
2eq7FADDihydrolipoyl dehydrogenase/0.451
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.448
1grbFADGlutathione reductase, mitochondrial1.8.1.70.446
1f8wFADNADH peroxidase1.11.1.10.444
3urhFADDihydrolipoyl dehydrogenase/0.444
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
1yqzFADCoenzyme A disulfide reductase/0.441
1zx9FADMercuric reductase1.16.1.10.441