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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.688
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.665
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.647
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.639
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.630
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.628
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.616
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.598
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.594
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.593
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.593
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.593
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.592
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.585
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.583
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.577
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.566
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.565
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.565
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.562
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.560
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.556
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
3dfcANPDeath-associated protein kinase 12.7.11.10.489
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.488
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.486
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.485
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4fv6E57Mitogen-activated protein kinase 12.7.11.240.484
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2ojj82AMitogen-activated protein kinase 12.7.11.240.479
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.474
2ijmADPFocal adhesion kinase 12.7.10.20.471
5av2KMPDeath-associated protein kinase 12.7.11.10.470
4ysjADPCalmodulin-like domain protein kinase/0.469
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4otiMI1Serine/threonine-protein kinase N1/0.468
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.467
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.466
1jklANPDeath-associated protein kinase 12.7.11.10.465
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4anmWULCasein kinase II subunit alpha2.7.11.10.461
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2f2uM77Rho-associated protein kinase 22.7.11.10.456
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2y9qANPMitogen-activated protein kinase 12.7.11.240.454
3lltANPProtein serine/threonine kinase-1/0.454
2j0lANPFocal adhesion kinase 12.7.10.20.453
2etrY27Rho-associated protein kinase 12.7.11.10.452
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3i60E86Mitogen-activated protein kinase 12.7.11.240.452
4h3qANPMitogen-activated protein kinase 12.7.11.240.452
3ncz3NCRho-associated protein kinase 12.7.11.10.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
5av3KMPDeath-associated protein kinase 12.7.11.10.449
4qnyANPMitogen activated protein kinase, putative/0.448
2pvmP29Casein kinase II subunit alpha2.7.11.10.446
1w8cN69Cyclin-dependent kinase 22.7.11.220.445
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.445
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.444
1qmzATPCyclin-dependent kinase 22.7.11.220.443
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3juhANPCasein kinase II subunit alpha2.7.11.10.442
4l9i8PRRhodopsin kinase/0.441
4aqc88ATyrosine-protein kinase JAK2/0.440
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440