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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.678
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.670
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.646
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.644
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.644
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.640
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.640
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.636
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.633
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.631
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.631
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.623
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.619
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.618
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.605
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.605
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.600
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.599
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.596
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.595
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.568
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.566
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.560
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.528
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.525
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.505
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.502
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.502
2ojj82AMitogen-activated protein kinase 12.7.11.240.501
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
4fv6E57Mitogen-activated protein kinase 12.7.11.240.498
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.494
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.493
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.492
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2y9qANPMitogen-activated protein kinase 12.7.11.240.490
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.483
5av2KMPDeath-associated protein kinase 12.7.11.10.482
1jklANPDeath-associated protein kinase 12.7.11.10.480
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
3dfcANPDeath-associated protein kinase 12.7.11.10.479
3i60E86Mitogen-activated protein kinase 12.7.11.240.475
3ncz3NCRho-associated protein kinase 12.7.11.10.473
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.465
4h3qANPMitogen-activated protein kinase 12.7.11.240.464
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.463
4otiMI1Serine/threonine-protein kinase N1/0.463
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.461
4anmWULCasein kinase II subunit alpha2.7.11.10.460
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4fmqANPMitogen-activated protein kinase 12.7.11.240.458
2yaaATPDeath-associated protein kinase 2/0.457
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.457
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4qnyANPMitogen activated protein kinase, putative/0.457
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2ijmADPFocal adhesion kinase 12.7.10.20.455
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.455
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2f2uM77Rho-associated protein kinase 22.7.11.10.453
2pvmP29Casein kinase II subunit alpha2.7.11.10.453
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4hvi19STyrosine-protein kinase JAK32.7.10.20.453
4nifANPMitogen-activated protein kinase 12.7.11.240.453
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4ysjADPCalmodulin-like domain protein kinase/0.451
4e6d0NUTyrosine-protein kinase JAK2/0.450
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.449
2etrY27Rho-associated protein kinase 12.7.11.10.448
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.448
5cvfATPCasein kinase II subunit alpha2.7.11.10.448
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
3juhANPCasein kinase II subunit alpha2.7.11.10.445
5av3KMPDeath-associated protein kinase 12.7.11.10.445
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1qmzATPCyclin-dependent kinase 22.7.11.220.441
2c6lDT4Cyclin-dependent kinase 22.7.11.220.441
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.440