sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 1.000 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.518 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.516 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.508 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.501 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.490 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.487 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.478 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.473 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.472 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.465 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.461 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.460 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.460 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.455 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.453 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.451 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.449 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.449 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.445 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.445 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.443 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.442 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3h59 | H59 | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.440 |