sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2q2z | MKK | Kinesin-like protein KIF11 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2q2z | MKK | Kinesin-like protein KIF11 | / | 1.000 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.631 | |
| 2g1q | N9H | Kinesin-like protein KIF11 | / | 0.616 | |
| 1q0b | NAT | Kinesin-like protein KIF11 | / | 0.591 | |
| 2x7d | EGB | Kinesin-like protein KIF11 | / | 0.585 | |
| 1x88 | NAT | Kinesin-like protein KIF11 | / | 0.574 | |
| 3k3b | L31 | Kinesin-like protein KIF11 | / | 0.572 | |
| 2fme | 3QC | Kinesin-like protein KIF11 | / | 0.566 | |
| 2x7e | X7E | Kinesin-like protein KIF11 | / | 0.562 | |
| 4bbg | V02 | Kinesin-like protein KIF11 | / | 0.560 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.558 | |
| 2ieh | MOY | Kinesin-like protein KIF11 | / | 0.557 | |
| 3k5e | K5E | Kinesin-like protein KIF11 | / | 0.557 | |
| 3ken | ZZD | Kinesin-like protein KIF11 | / | 0.549 | |
| 2wog | ZZD | Kinesin-like protein KIF11 | / | 0.546 | |
| 2x7c | KZ9 | Kinesin-like protein KIF11 | / | 0.545 | |
| 2x2r | X2O | Kinesin-like protein KIF11 | / | 0.541 | |
| 4a5y | G7X | Kinesin-like protein KIF11 | / | 0.537 | |
| 2xae | 2XA | Kinesin-like protein KIF11 | / | 0.528 | |
| 4as7 | 6LX | Kinesin-like protein KIF11 | / | 0.494 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.464 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.463 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.462 | |
| 4iay | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.461 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.458 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.457 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.455 | |
| 2bxe | 1FL | Serum albumin | / | 0.454 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.454 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.452 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.451 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.451 | |
| 4ekl | 0RF | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.451 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.450 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.450 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.448 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.447 | |
| 2w1h | L0F | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3eb0 | DRK | Uncharacterized protein | / | 0.445 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.445 | |
| 5ify | TRH | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 1err | RAL | Estrogen receptor | / | 0.444 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.444 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 3r8p | Z46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.442 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.441 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.440 |