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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2q1tNADPutative nucleotide sugar epimerase/ dehydratase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/1.000
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.617
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.518
1kvrNADUDP-glucose 4-epimerase5.1.3.20.510
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.509
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.506
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.494
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.494
4yagNAIC alpha-dehydrogenase/0.491
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.482
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.480
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.479
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.476
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.476
2c20NADUDP-glucose 4-epimerase/0.472
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.472
3gqvNAPEnoyl reductase LovC10.472
4yaiNAIC alpha-dehydrogenase/0.470
1naiNADUDP-glucose 4-epimerase5.1.3.20.468
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.466
1nytNAPShikimate dehydrogenase (NADP(+))/0.465
4j7xNAPSepiapterin reductase1.1.1.1530.462
3d3wNAPL-xylulose reductase1.1.1.100.461
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.457
4gid0GHBeta-secretase 13.4.23.460.457
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.456
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.456
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.456
2il2LIXRenin3.4.23.150.455
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
1g6kNADGlucose 1-dehydrogenase1.1.1.470.452
3b70NAPEnoyl reductase LovC10.452
4hwkNAPSepiapterin reductase1.1.1.1530.452
5jy1NADPutative short-chain dehydrogenase/reductase/0.452
1nahNADUDP-glucose 4-epimerase5.1.3.20.451
2c12FADNitroalkane oxidase1.7.3.10.451
2p5uNADUDP-glucose 4-epimerase/0.451
4lcjNADC-terminal-binding protein 2/0.451
1bil0IURenin3.4.23.150.449
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.448
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.448
5jydNADShort chain dehydrogenase/0.448
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.447
4usrFADMonooxygenase/0.447
2givACOHistone acetyltransferase KAT8/0.446
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.446
3d91REMRenin3.4.23.150.445
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.445
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
1d0mBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.444
1i3lNADUDP-glucose 4-epimerase/0.443
4ambDUDPutative glycosyl transferase/0.443
2omeNADC-terminal-binding protein 2/0.442
3f1kNAPUncharacterized oxidoreductase YciK10.442
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.440
4gh5NADShort-chain dehydrogenase/reductase SDR/0.440