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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdlTOLAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdlTOLAldose reductase1.1.1.211.000
2fzbTOLAldose reductase1.1.1.210.637
1ah3TOLAldose reductase1.1.1.210.629
2fzdTOLAldose reductase1.1.1.210.589
2pdh47DAldose reductase1.1.1.210.560
2fz8ZSTAldose reductase1.1.1.210.535
1zuaTOLAldo-keto reductase family 1 member B101.1.10.533
2pdfZSTAldose reductase1.1.1.210.532
3ghrLDTAldose reductase1.1.1.210.530
2i16LDTAldose reductase1.1.1.210.518
4wevSUZAldo-keto reductase family 1 member B101.1.10.510
2pdiZSTAldose reductase1.1.1.210.509
3ghsLDTAldose reductase1.1.1.210.503
2duzZSTAldose reductase1.1.1.210.491
2dv0ZSTAldose reductase1.1.1.210.486
3ghtLDTAldose reductase1.1.1.210.486
2hv5ZSTAldose reductase1.1.1.210.483
3m64393Aldose reductase1.1.1.210.479
1ry8RUTAldo-keto reductase family 1 member C3/0.476
2fz9ZSTAldose reductase1.1.1.210.475
2ikj393Aldose reductase1.1.1.210.473
1z3n3NAAldose reductase1.1.1.210.471
2hvoZSTAldose reductase1.1.1.210.471
2i17LDTAldose reductase1.1.1.210.470
1zq5E04Aldo-keto reductase family 1 member C3/0.467
2pzn393Aldose reductase1.1.1.210.467
5liu388Aldo-keto reductase family 1 member B101.1.10.466
3ld5LDTAldose reductase1.1.1.210.465
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2iki388Aldose reductase1.1.1.210.464
3ghuLDTAldose reductase1.1.1.210.461
2pdmZSTAldose reductase1.1.1.210.460
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4gca2X9Aldose reductase1.1.1.210.458
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.457
2f3815MAldo-keto reductase family 1 member C3/0.457
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
3lenZSTAldose reductase1.1.1.210.456
1z8962PAldose reductase1.1.1.210.455
2hvnZSTAldose reductase1.1.1.210.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.455
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.453
4fam0SZAldo-keto reductase family 1 member C3/0.453
1ry0PG2Aldo-keto reductase family 1 member C3/0.451
2vbpVB1Isopenicillin N synthase1.21.3.10.451
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.449
2ikhLITAldose reductase1.1.1.210.447
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.447
3g5eQ74Aldose reductase1.1.1.210.446
2pdp393Aldose reductase1.1.1.210.445
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4mqt2CUMuscarinic acetylcholine receptor M2/0.445
3v94WYQPhosphodiesterase/0.444
4kxjP34Nucleoprotein/0.444
2pdu393Aldose reductase1.1.1.210.443
2vrjNCWBeta-glucosidase A3.2.1.210.443
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.443
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.443
1dpmEBPParathion hydrolase3.1.8.10.442
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.442
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
1xf0ASDAldo-keto reductase family 1 member C3/0.441
3m0iZSTAldose reductase1.1.1.210.441
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440