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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2p7zOHTEstrogen-related receptor gamma

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2p7zOHTEstrogen-related receptor gamma/1.000
2ewpTXFEstrogen-related receptor gamma/0.644
1s9qOHTEstrogen-related receptor gamma/0.637
2gpuOHTEstrogen-related receptor gamma/0.599
2gpvOHTEstrogen-related receptor gamma/0.594
2qe4JJ3Estrogen receptor/0.557
1sj0E4DEstrogen receptor/0.548
1yinCM3Estrogen receptor/0.541
1errRALEstrogen receptor/0.539
1xqcAEJEstrogen receptor/0.533
1xp6AIUEstrogen receptor/0.528
1uomPTIEstrogen receptor/0.518
1s9pDESEstrogen-related receptor gamma/0.517
2jfaRALEstrogen receptor/0.516
2jf9OHTEstrogen receptor/0.509
2fszOHTEstrogen receptor beta/0.506
2ovhAS0Progesterone receptor/0.506
1ndeMONEstrogen receptor beta/0.497
1qknRALEstrogen receptor beta/0.494
2bj4OHTEstrogen receptor/0.489
4qo9627Serine/threonine-protein kinase 242.7.11.10.488
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.487
1nhz486Glucocorticoid receptor/0.483
3wv9FEGHmd co-occurring protein HcgE/0.478
4y8wSTRSteroid 21-hydroxylase/0.472
2itqITQEpidermal growth factor receptor2.7.10.10.471
2ovmAS0Progesterone receptor/0.471
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.471
3vt8YI3Vitamin D3 receptor/0.470
4a2jAS0Progesterone receptor/0.470
3is9AC7Gag-Pol polyprotein2.7.7.490.469
3w5p4OAVitamin D3 receptor/0.468
4othDRNSerine/threonine-protein kinase N1/0.467
4em9TCEPeroxisome proliferator-activated receptor gamma/0.466
2fzhDH1Dihydrofolate reductase1.5.1.30.464
4bchT7ZCyclin-dependent kinase 92.7.11.220.463
1mznBM6Retinoic acid receptor RXR-alpha/0.462
5hs1VORLanosterol 14-alpha demethylase/0.462
3vtcTK3Vitamin D3 receptor/0.461
3cseN22Uncharacterized protein/0.460
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4iarERM5-hydroxytryptamine receptor 1B/0.460
3pm0BHFCytochrome P450 1B1/0.458
4nc3ERM5-hydroxytryptamine receptor 2B/0.458
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.456
4j6dTESCytochrome P450 monooxygenase/0.456
2hasC3OVitamin D3 receptor/0.454
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
5uviZMAAdenosine receptor A2a/0.454
2w98P1ZProstaglandin reductase 21.3.1.480.453
3vt9YI4Vitamin D3 receptor/0.453
3vtdTKDVitamin D3 receptor/0.453
1s19MC9Vitamin D3 receptor/0.452
2w8y486Progesterone receptor/0.452
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.452
1o5rFR9Adenosine deaminase3.5.4.40.451
2c7xNRBCytochrome P450 monooxygenase PikC/0.451
2pogWSTEstrogen receptor/0.451
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.451
4g1z0VPVitamin D3 receptor A/0.451
4j6cSTRCytochrome P450 monooxygenase/0.451
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.450
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.450
4i8vBHFCytochrome P450 1A11.14.14.10.450
4iaq2GM5-hydroxytryptamine receptor 1B/0.450
3a1l2CCCytochrome P450/0.449
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.449
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.449
2qjySMACytochrome b/0.448
3irxUDRGag-Pol polyprotein2.7.7.490.448
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.448
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4ia1BIVVitamin D3 receptor A/0.448
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.448
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1cjwCOTSerotonin N-acetyltransferase/0.447
1iyzNDPProbable quinone oxidoreductase/0.447
1kzjCB3Thymidylate synthase/0.447
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.447
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.447
3w0hW12Vitamin D3 receptor/0.447
4enhFVXCholesterol 24-hydroxylase/0.447
2hb7O1CVitamin D3 receptor/0.446
2zlcVDXVitamin D3 receptor/0.446
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
1lhvNOGSex hormone-binding globulin/0.445
1rdtL79Retinoic acid receptor RXR-alpha/0.445
1txiTX5Vitamin D3 receptor/0.445
1vj3TABDihydrofolate reductase1.5.1.30.445
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.445
3uvvREARetinoic acid receptor RXR-alpha/0.445
3vtbTKAVitamin D3 receptor/0.445
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.445
1aoeGW3Dihydrofolate reductase1.5.1.30.444
2i0ePDSProtein kinase C beta type2.7.11.130.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
3g5hYTTMycocyclosin synthase1.14.21.90.444
4iv41GSEstrogen receptor/0.444
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1og5SWFCytochrome P450 2C9/0.443
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.443
3vg9ZMAAdenosine receptor A2a/0.443
4jlj1NMDeoxycytidine kinase2.7.1.740.443
4r21STRCytochrome P450 family 17 polypeptide 2/0.443
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.443
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.442
2yiuSMACytochrome b/0.442
4qa2SHHHistone deacetylase 83.5.1.980.442
1k749CRRetinoic acid receptor RXR-alpha/0.441
1mb9ATPCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.441
2hcdBIVVitamin D3 receptor A/0.441
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.441
3w0iO11Vitamin D3 receptor/0.441
3w0jT08Vitamin D3 receptor/0.441
4ejh0QACytochrome P450 2A131.14.14.10.441
2bfyH1NAurora kinase B-A2.7.11.10.440
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.440
2btsU32Cyclin-dependent kinase 22.7.11.220.440
2itpAEEEpidermal growth factor receptor2.7.10.10.440
2jn3JN3Fatty acid-binding protein, liver/0.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
2w4qCBWProstaglandin reductase 21.3.1.480.440
4ia7BIVVitamin D3 receptor A/0.440
4ib4ERM5-hydroxytryptamine receptor 2B/0.440
4qa0SHHHistone deacetylase 83.5.1.980.440
4ruoBIVVitamin D3 receptor A/0.440
4rw4494Gag-Pol polyprotein2.7.7.490.440