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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2owvSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2owvSAHDiphthine synthase/1.000
2dekSAHDiphthine synthase/0.812
2e16SAHDiphthine synthase/0.773
2eglSAHDiphthine synthase/0.766
2e8hSAHDiphthine synthase/0.763
2e08SAHDiphthine synthase/0.734
2ek7SAHDiphthine synthase/0.722
2p6lSAHDiphthine synthase/0.719
2dxwSAHDiphthine synthase/0.711
2egbSAHDiphthine synthase/0.693
2dxvSAHDiphthine synthase/0.692
2en5SAHDiphthine synthase/0.691
2owuSAHDiphthine synthase/0.681
2ejjSAHDiphthine synthase/0.677
2egsSAHDiphthine synthase/0.675
2eeqSAHDiphthine synthase/0.672
2emrSAHDiphthine synthase/0.670
2e8qSAHDiphthine synthase/0.669
2e8sSAHDiphthine synthase/0.668
1vceSAHDiphthine synthase/0.665
2pb4SAHDiphthine synthase/0.658
2pcmSAHDiphthine synthase/0.658
2ehlSAHDiphthine synthase/0.656
2el0SAHDiphthine synthase/0.655
2p6iSAHDiphthine synthase/0.655
2eh5SAHDiphthine synthase/0.654
2dsgSAHDiphthine synthase/0.648
2e07SAHDiphthine synthase/0.646
2ed5SAHDiphthine synthase/0.646
2p6kSAHDiphthine synthase/0.645
2owkSAHDiphthine synthase/0.643
2dv7SAHDiphthine synthase/0.642
2p6dSAHDiphthine synthase/0.639
2ejkSAHDiphthine synthase/0.638
2dv4SAHDiphthine synthase/0.636
2eniSAHDiphthine synthase/0.636
2pchSAHDiphthine synthase/0.632
1wngSAHDiphthine synthase/0.629
2emuSAHDiphthine synthase/0.629
2hr8SAHDiphthine synthase/0.629
2z6rSAHDiphthine synthase/0.621
2pciSAHDiphthine synthase/0.620
2p2xSAHDiphthine synthase/0.618
2ekaSAHDiphthine synthase/0.617
2ek2SAHDiphthine synthase/0.616
2huxSAHDiphthine synthase/0.616
2e17SAHDiphthine synthase/0.615
2huqSAHDiphthine synthase/0.615
2dv3SAHDiphthine synthase/0.612
2e15SAHDiphthine synthase/0.612
2dshSAHDiphthine synthase/0.611
2eh2SAHDiphthine synthase/0.610
2p5fSAHDiphthine synthase/0.596
2eleSAHDiphthine synthase/0.589
2dsiSAHDiphthine synthase/0.587
2pb6SAHDiphthine synthase/0.587
2p5cSAHDiphthine synthase/0.583
2owfSAHDiphthine synthase/0.582
2ek4SAHDiphthine synthase/0.581
2ed3SAHDiphthine synthase/0.579
2e7rSAHDiphthine synthase/0.578
2eldSAHDiphthine synthase/0.573
2e4nSAHDiphthine synthase/0.567
2el3SAHDiphthine synthase/0.559
2ek3SAHDiphthine synthase/0.558
2dxxSAHDiphthine synthase/0.557
2pckSAHDiphthine synthase/0.557
2pb5SAHDiphthine synthase/0.555
2eh4SAHDiphthine synthase/0.551
2huvSAHDiphthine synthase/0.550
2ejzSAHDiphthine synthase/0.548
2pcgSAHDiphthine synthase/0.548
2hutSAHDiphthine synthase/0.547
2pcaSAHDiphthine synthase/0.543
2p9dSAHDiphthine synthase/0.541
2dv5SAHDiphthine synthase/0.532
2e8rSAHDiphthine synthase/0.532
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.478
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.475
1tqf32PBeta-secretase 13.4.23.460.473
2owgSAHDiphthine synthase/0.473
2xhd7T9Glutamate receptor 2/0.471
1kkq471Peroxisome proliferator-activated receptor alpha/0.463
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.462
2y3sTIRTamL/0.462
3gw9VNILanosterol 14-alpha-demethylase/0.461
1x1dSAHC-20 methyltransferase/0.459
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4q71FADBifunctional protein PutA/0.459
1f8wFADNADH peroxidase1.11.1.10.458
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1lbcCYZGlutamate receptor 2/0.457
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.457
2ifaFMNUncharacterized protein/0.457
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.457
1x1bSAHC-20 methyltransferase/0.456
3oht1N1Mitogen-activated protein kinase/0.456
4bfxZVXPantothenate kinase2.7.1.330.456
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.455
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.455
4gxs0YSGlutamate receptor 2/0.455
1zeoC01Peroxisome proliferator-activated receptor gamma/0.454
3g70A5TRenin3.4.23.150.454
4h3f10OBeta-secretase 13.4.23.460.453
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.452
1me6IVSPlasmepsin-23.4.23.390.452
2q5g1FAPeroxisome proliferator-activated receptor delta/0.452
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3bc3OPTCathepsin L13.4.22.150.452
3clrFADElectron transfer flavoprotein subunit alpha/0.452
4g3jVNTLanosterol 14-alpha-demethylase/0.452
1x1aSAMC-20 methyltransferase/0.451
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.450
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.450
4ji91M3Tyrosine-protein kinase JAK2/0.450
1x1cSAHC-20 methyltransferase/0.449
1xe55FEPlasmepsin-23.4.23.390.449
2a94AP0L-lactate dehydrogenase1.1.1.270.449
3f3sNADLambda-crystallin homolog/0.449
3ijoB4DGlutamate receptor 2/0.449
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.449
4nbwNADShort-chain dehydrogenase/reductase SDR/0.449
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3ut5LOCTubulin beta chain/0.448
4f5yC2EStimulator of interferon genes protein/0.448
4frkDWDBeta-secretase 13.4.23.460.448
1fm4DXCMajor pollen allergen Bet v 1-L/0.447
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
2b53D23Cyclin-dependent kinase 22.7.11.220.447
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.447
3lpkZ76Beta-secretase 13.4.23.460.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4m83ERYOleandomycin glycosyltransferase2.4.10.447
1juvNDPDihydrofolate reductase1.5.1.30.446
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.446
2q4bNAPUncharacterized protein At5g02240/0.446
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.446
1bim0QBRenin3.4.23.150.445
1kp3ATPArgininosuccinate synthase6.3.4.50.445
1w6hTITPlasmepsin-23.4.23.390.445
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2rhgIGPTryptophan synthase alpha chain/0.445
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.445
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.445
3wb2YGPUncharacterized protein MJ0488/0.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4jx1CAHCamphor 5-monooxygenase1.14.15.10.445
4oztP1AEcdysone receptor, putative/0.445
5fm7ADPRuvB-like helicase/0.445
1f8fNADBenzyl alcohol dehydrogenase/0.444
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
2p5uNADUDP-glucose 4-epimerase/0.444
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.444
2rcyNAPPyrroline-5-carboxylate reductase/0.444
3lpiZ74Beta-secretase 13.4.23.460.444
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.444
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4uymVOR14-alpha sterol demethylase Cyp51B/0.444
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
3to6LYS_CMCHistone acetyltransferase ESA1/0.443
4egbNADdTDP-glucose 4,6-dehydratase/0.443
1g63FMNEpidermin decarboxylase4.1.10.442
2bjfDXCCholoylglycine hydrolase3.5.1.240.442
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3slkNDPPolyketide synthase extender module 2/0.442
3zh8C58Protein kinase C iota type2.7.11.130.442
4i8zG08Gag-Pol polyprotein3.4.23.160.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
2bf4FMNNADPH--cytochrome P450 reductase/0.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
3crzFADFerredoxin--NADP+ reductase/0.441
3oagLPQRenin3.4.23.150.441
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
4djy0KRBeta-secretase 13.4.23.460.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1xe65FPPlasmepsin-23.4.23.390.440
1yb5NAPQuinone oxidoreductase1.6.5.50.440
2c29NAPDihydroflavonol 4-reductase/0.440
2gv8NDPThiol-specific monooxygenase1.14.130.440
2iko7IGRenin3.4.23.150.440