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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.584
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.577
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.576
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.576
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.531
2r9zFADGlutathione amide reductase/0.527
1grhFADGlutathione reductase, mitochondrial1.8.1.70.513
4j56FADThioredoxin reductase 21.8.1.90.511
1greFADGlutathione reductase, mitochondrial1.8.1.70.509
1febFADTrypanothione reductase1.8.1.120.508
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.506
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.505
1grgFADGlutathione reductase, mitochondrial1.8.1.70.503
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.503
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.500
3grsFADGlutathione reductase, mitochondrial1.8.1.70.500
1gerFADGlutathione reductase1.8.1.70.495
2v6oFADThioredoxin glutathione reductase/0.493
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.492
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.490
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.479
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.475
2rabFADGlutathione amide reductase/0.470
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.468
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.467
4nevFADTrypanothione reductase/0.466
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.463
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.463
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.463
1zx9FADMercuric reductase1.16.1.10.462
1feaFADTrypanothione reductase1.8.1.120.461
1zk7FADMercuric reductase1.16.1.10.458
1graFADGlutathione reductase, mitochondrial1.8.1.70.457
1bzlFADTrypanothione reductase1.8.1.120.454
1geuFADGlutathione reductase1.8.1.70.454
3ic9FADPutative dihydrolipoamide dehydrogenase/0.452
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.450
4jq9FADDihydrolipoyl dehydrogenase/0.447
2eq9FADDihydrolipoyl dehydrogenase/0.440