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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hvnZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hvnZSTAldose reductase1.1.1.211.000
2fz9ZSTAldose reductase1.1.1.210.748
2hv5ZSTAldose reductase1.1.1.210.708
2dv0ZSTAldose reductase1.1.1.210.699
2pdxZSTAldose reductase1.1.1.210.699
2hvoZSTAldose reductase1.1.1.210.682
1z3n3NAAldose reductase1.1.1.210.675
3g5eQ74Aldose reductase1.1.1.210.661
1us0LDTAldose reductase1.1.1.210.647
3m4h388Aldose reductase1.1.1.210.637
3m64393Aldose reductase1.1.1.210.637
2pdmZSTAldose reductase1.1.1.210.627
2ikj393Aldose reductase1.1.1.210.626
2fz8ZSTAldose reductase1.1.1.210.620
2i16LDTAldose reductase1.1.1.210.619
3lboLDTAldose reductase1.1.1.210.619
3lqlLDTAldose reductase1.1.1.210.615
3mb9ZSTAldose reductase1.1.1.210.613
2pdbZSTAldose reductase1.1.1.210.609
2pdh47DAldose reductase1.1.1.210.609
3ghuLDTAldose reductase1.1.1.210.609
2pdfZSTAldose reductase1.1.1.210.601
1pwlBFIAldose reductase1.1.1.210.588
2pzn393Aldose reductase1.1.1.210.587
1z8962PAldose reductase1.1.1.210.585
2pd5ZSTAldose reductase1.1.1.210.585
4gca2X9Aldose reductase1.1.1.210.582
1t40ID5Aldose reductase1.1.1.210.581
2pdp393Aldose reductase1.1.1.210.579
3lenZSTAldose reductase1.1.1.210.578
2qxwLDTAldose reductase1.1.1.210.576
3m0iZSTAldose reductase1.1.1.210.575
2pdn47DAldose reductase1.1.1.210.572
2fzdTOLAldose reductase1.1.1.210.571
4yu153NAldose reductase1.1.1.210.568
1t41ID5Aldose reductase1.1.1.210.567
2pdiZSTAldose reductase1.1.1.210.567
2pdc393Aldose reductase1.1.1.210.563
3ghrLDTAldose reductase1.1.1.210.562
2pdg47DAldose reductase1.1.1.210.561
3mc5393Aldose reductase1.1.1.210.561
2pdu393Aldose reductase1.1.1.210.556
3lz5LDTAldose reductase1.1.1.210.553
3t423T4Aldose reductase1.1.1.210.553
3ghsLDTAldose reductase1.1.1.210.543
2duxZSTAldose reductase1.1.1.210.541
2ikhLITAldose reductase1.1.1.210.539
2pdlTOLAldose reductase1.1.1.210.535
2iki388Aldose reductase1.1.1.210.532
2i17LDTAldose reductase1.1.1.210.529
3ghtLDTAldose reductase1.1.1.210.524
1zuaTOLAldo-keto reductase family 1 member B101.1.10.522
2pdj393Aldose reductase1.1.1.210.522
2duzZSTAldose reductase1.1.1.210.516
1frbZSTAldose reductase-related protein 2/0.498
1ieiZESAldose reductase1.1.1.210.498
2pdyFIDAldose reductase1.1.1.210.498
2pdq47DAldose reductase1.1.1.210.495
1ah3TOLAldose reductase1.1.1.210.480
1ekoI84Aldose reductase1.1.1.210.478
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.470
3s3gTLTAldose reductase1.1.1.210.470
1zgbA1EAcetylcholinesterase3.1.1.70.468
3ld5LDTAldose reductase1.1.1.210.468
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
5liu388Aldo-keto reductase family 1 member B101.1.10.460
4gabFIDAldo-keto reductase family 1 member B101.1.10.459
2fzbTOLAldose reductase1.1.1.210.458
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2cekN8TAcetylcholinesterase3.1.1.70.456
4e0u0MVCyclic dipeptide N-prenyltransferase/0.456
1el3I84Aldose reductase1.1.1.210.455
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1ef3FIDAldose reductase1.1.1.210.454
2f2kTGGAldose reductase1.1.1.210.454
4msk2C8Tankyrase-12.4.2.300.453
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.452
2pd9FIDAldose reductase1.1.1.210.452
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2xufTZ4Acetylcholinesterase3.1.1.70.449
3ocx2AMLipoprotein E/0.447
1ry0PG2Aldo-keto reductase family 1 member C3/0.446
2xuhTZ4Acetylcholinesterase3.1.1.70.446
1odcA8BAcetylcholinesterase3.1.1.70.445
1xf0ASDAldo-keto reductase family 1 member C3/0.444
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2pdkSBIAldose reductase1.1.1.210.442
1lnmDTXBilin-binding protein/0.441
2gywOBIAcetylcholinesterase3.1.1.70.441
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.441
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2xujTZ5Acetylcholinesterase3.1.1.70.440