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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2henADPEphrin type-B receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2henADPEphrin type-B receptor 22.7.10.11.000
2qoqANPEphrin type-A receptor 32.7.10.10.637
2qo7ANPEphrin type-A receptor 32.7.10.10.612
2ijmATPFocal adhesion kinase 12.7.10.20.523
4qnyANPMitogen activated protein kinase, putative/0.502
4c3pACPAurora kinase A2.7.11.10.493
2qo9ANPEphrin type-A receptor 32.7.10.10.492
3c4wATPRhodopsin kinase/0.491
2qocANPEphrin type-A receptor 32.7.10.10.487
1i44ACPInsulin receptor2.7.10.10.481
2j0lANPFocal adhesion kinase 12.7.10.20.478
1mqbANPEphrin type-A receptor 22.7.10.10.470
3bu5ATPInsulin receptor2.7.10.10.469
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.468
5l8lADPAurora kinase A2.7.11.10.466
5dosATPAurora kinase A2.7.11.10.465
2wqeADPAurora kinase A2.7.11.10.463
4gk3L87Ephrin type-A receptor 32.7.10.10.461
4qmlANPSerine/threonine-protein kinase 242.7.11.10.461
4s33ANPMitogen-activated protein kinase 12.7.11.240.460
4eooATPCyclin-dependent kinase 22.7.11.220.457
4j99ACPFibroblast growth factor receptor 2/0.457
3qc9ADPRhodopsin kinase/0.456
4xlvACPInsulin receptor2.7.10.10.456
3zewSTUEphrin type-B receptor 42.7.10.10.455
5dnrATPAurora kinase A2.7.11.10.451
4ysjADPCalmodulin-like domain protein kinase/0.450
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.449
2xvdAS6Ephrin type-B receptor 42.7.10.10.449
4riyADPEpidermal growth factor receptor2.7.10.10.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
3c4zADPRhodopsin kinase/0.446
4gk4L90Ephrin type-A receptor 32.7.10.10.446
4k33ACPFibroblast growth factor receptor 32.7.10.10.445
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.444
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
4btjATPTau-tubulin kinase 12.7.11.10.442
4j95ACPFibroblast growth factor receptor 2/0.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.441
4btjADPTau-tubulin kinase 12.7.11.10.441