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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.31.000
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.644
3qlrNDPDihydrofolate reductase1.5.1.30.615
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.605
3qlsNDPDihydrofolate reductase1.5.1.30.604
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.600
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.586
1dr3TAPDihydrofolate reductase1.5.1.30.573
1dr2TAPDihydrofolate reductase1.5.1.30.572
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.567
1dr5NAPDihydrofolate reductase1.5.1.30.561
1dg8NDPDihydrofolate reductase1.5.1.30.559
1rx1NAPDihydrofolate reductase1.5.1.30.557
1ia1NDPDihydrofolate reductase1.5.1.30.552
5eccNAPDehydrofolate reductase type I/0.552
1ai9NDPDihydrofolate reductase1.5.1.30.550
4kl9NDPDihydrofolate reductase1.5.1.30.547
2w3bNDPDihydrofolate reductase1.5.1.30.546
1m78NDPDihydrofolate reductase1.5.1.30.543
3nxxNDPDihydrofolate reductase1.5.1.30.541
3d84NDPDihydrofolate reductase1.5.1.30.537
3tqaNDPDihydrofolate reductase/0.536
4m6jNDPDihydrofolate reductase1.5.1.30.535
2cig1DGDihydrofolate reductase1.5.1.30.534
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.532
1drhNAPDihydrofolate reductase1.5.1.30.530
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.527
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.508
1ia4TQ6Dihydrofolate reductase1.5.1.30.485
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
2q4wFADCytokinin dehydrogenase 71.5.99.120.459
1ma0NADAlcohol dehydrogenase class-31.1.1.10.456
4bfxZVXPantothenate kinase2.7.1.330.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.453
4q72FADBifunctional protein PutA/0.453
3oafOAGDihydrofolate reductase1.5.1.30.450
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.450
4q71FADBifunctional protein PutA/0.448
1ia3TQ5Dihydrofolate reductase1.5.1.30.447
3c1y2BADNA integrity scanning protein DisA/0.447
1y0s331Peroxisome proliferator-activated receptor delta/0.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
4bb3KKAIsopenicillin N synthase1.21.3.10.442
4gl4NAIAlcohol dehydrogenase class-3/0.442
3pm9FADPutative oxidoreductase/0.441
3q43D66M1 family aminopeptidase3.4.110.440
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440