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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fzdTOLAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fzdTOLAldose reductase1.1.1.211.000
1ah3TOLAldose reductase1.1.1.210.631
2pdlTOLAldose reductase1.1.1.210.601
1zuaTOLAldo-keto reductase family 1 member B101.1.10.571
2pdxZSTAldose reductase1.1.1.210.564
2pdh47DAldose reductase1.1.1.210.557
2fz9ZSTAldose reductase1.1.1.210.552
2pdfZSTAldose reductase1.1.1.210.541
4wevSUZAldo-keto reductase family 1 member B101.1.10.538
2fzbTOLAldose reductase1.1.1.210.535
2hvnZSTAldose reductase1.1.1.210.528
3m4h388Aldose reductase1.1.1.210.521
2dv0ZSTAldose reductase1.1.1.210.519
5liu388Aldo-keto reductase family 1 member B101.1.10.512
3lqlLDTAldose reductase1.1.1.210.511
4gca2X9Aldose reductase1.1.1.210.510
3g5eQ74Aldose reductase1.1.1.210.502
3lboLDTAldose reductase1.1.1.210.500
2hv5ZSTAldose reductase1.1.1.210.493
1z3n3NAAldose reductase1.1.1.210.492
3m64393Aldose reductase1.1.1.210.492
1ry0PG2Aldo-keto reductase family 1 member C3/0.486
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.486
3lz5LDTAldose reductase1.1.1.210.484
4fam0SZAldo-keto reductase family 1 member C3/0.482
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.481
3lenZSTAldose reductase1.1.1.210.480
3ghuLDTAldose reductase1.1.1.210.479
1w6jR71Lanosterol synthase5.4.99.70.478
2pd9FIDAldose reductase1.1.1.210.478
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.478
3v35NTIAldose reductase1.1.1.210.478
2hvoZSTAldose reductase1.1.1.210.476
4y1bNAPAntE/0.475
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.472
2pdu393Aldose reductase1.1.1.210.472
2iki388Aldose reductase1.1.1.210.470
2ikj393Aldose reductase1.1.1.210.470
3mc5393Aldose reductase1.1.1.210.470
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.469
3m0iZSTAldose reductase1.1.1.210.469
1ekoI84Aldose reductase1.1.1.210.468
2pdj393Aldose reductase1.1.1.210.468
1z8962PAldose reductase1.1.1.210.467
1us0LDTAldose reductase1.1.1.210.466
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2fz8ZSTAldose reductase1.1.1.210.465
2qxwLDTAldose reductase1.1.1.210.464
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.463
2duxZSTAldose reductase1.1.1.210.462
4yu153NAldose reductase1.1.1.210.462
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
3mb9ZSTAldose reductase1.1.1.210.461
2pdp393Aldose reductase1.1.1.210.460
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
1t41ID5Aldose reductase1.1.1.210.458
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2i16LDTAldose reductase1.1.1.210.457
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.456
1ieiZESAldose reductase1.1.1.210.456
2f2kTGGAldose reductase1.1.1.210.456
2pdwFIDAldose reductase1.1.1.210.456
3zkyWT4Isopenicillin N synthase1.21.3.10.456
1xf0ASDAldo-keto reductase family 1 member C3/0.455
1zgcA2EAcetylcholinesterase3.1.1.70.455
3ghrLDTAldose reductase1.1.1.210.455
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.454
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1bk0ACVIsopenicillin N synthase1.21.3.10.453
2inzOHPAldose reductase1.1.1.210.453
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.453
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
1t40ID5Aldose reductase1.1.1.210.452
2pzn393Aldose reductase1.1.1.210.452
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
3v94WYQPhosphodiesterase/0.451
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.450
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.450
2nvcITAAldose reductase1.1.1.210.449
2wo7ASVIsopenicillin N synthase1.21.3.10.449
1zq5E04Aldo-keto reductase family 1 member C3/0.448
1ry8RUTAldo-keto reductase family 1 member C3/0.447
2ikhLITAldose reductase1.1.1.210.447
4arbC57Acetylcholinesterase3.1.1.70.447
1n5vNOMActVA 6 protein/0.446
2bjsACVIsopenicillin N synthase1.21.3.10.446
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.446
1ej3CZHAequorin-2/0.445
1hb3SCVIsopenicillin N synthase1.21.3.10.445
2vqqTFGHistone deacetylase 43.5.1.980.445
2w6cBM4Acetylcholinesterase3.1.1.70.445
3ghsLDTAldose reductase1.1.1.210.445
4a16H34Acetylcholinesterase3.1.1.70.445
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.445
1ef3FIDAldose reductase1.1.1.210.444
1upw444Oxysterols receptor LXR-beta/0.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
2xi4AFTAcetylcholinesterase3.1.1.70.444
2xviFADPutative flavin-containing monooxygenase/0.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.443
2pdbZSTAldose reductase1.1.1.210.443
2pdmZSTAldose reductase1.1.1.210.443
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.443
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4e32DWNMethyltransferase/0.442
4phlPILPhosphodiesterase/0.442
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2cbqTH2Neocarzinostatin/0.441
2pdq47DAldose reductase1.1.1.210.441
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.441
3t423T4Aldose reductase1.1.1.210.440
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.440
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.440