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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2eq8FADDihydrolipoyl dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2eq8FADDihydrolipoyl dehydrogenase/1.000
2eq9FADDihydrolipoyl dehydrogenase/0.608
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.538
4jq9FADDihydrolipoyl dehydrogenase/0.534
1zx9FADMercuric reductase1.16.1.10.530
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.529
1zk7FADMercuric reductase1.16.1.10.527
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.522
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.522
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.520
2eq6FADDihydrolipoyl dehydrogenase/0.519
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.518
2r9zFADGlutathione amide reductase/0.508
3ladFADDihydrolipoyl dehydrogenase/0.507
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.501
3ic9FADPutative dihydrolipoamide dehydrogenase/0.495
2yquFADDihydrolipoyl dehydrogenase/0.491
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.484
3urhFADDihydrolipoyl dehydrogenase/0.484
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.483
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.479
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.472
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.471
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.471
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.470
1grhFADGlutathione reductase, mitochondrial1.8.1.70.467
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.463
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.461
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.460
1greFADGlutathione reductase, mitochondrial1.8.1.70.457
1nhpFADNADH peroxidase1.11.1.10.457
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.454
3grsFADGlutathione reductase, mitochondrial1.8.1.70.453
1grgFADGlutathione reductase, mitochondrial1.8.1.70.452
1gerFADGlutathione reductase1.8.1.70.451
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.451
3icrFADCoenzyme A disulfide reductase/0.450
3cgbFADCoenzyme A disulfide reductase/0.448
3lb8FADPutidaredoxin reductase1.18.1.50.447
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
1febFADTrypanothione reductase1.8.1.120.446
1onfFADGlutathione reductase1.8.1.70.444
1bzlFADTrypanothione reductase1.8.1.120.442
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.442
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.441
4j56FADThioredoxin reductase 21.8.1.90.441
1graFADGlutathione reductase, mitochondrial1.8.1.70.440