sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 1.000 | |
| 2gh6 | CF3 | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.523 | |
| 2vcg | S17 | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.523 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.477 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.464 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.463 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.460 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.458 | |
| 3clx | X22 | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.455 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.453 | |
| 4phl | PIL | Phosphodiesterase | / | 0.453 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.451 | |
| 1qv1 | CZH | Obelin | / | 0.448 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 3il4 | ACO | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.448 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1uhh | CZP | Aequorin-2 | / | 0.446 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.444 | |
| 3tdk | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.444 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 3p9t | TCL | Repressor | / | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.441 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.440 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.440 |