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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.11.000
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.628
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.600
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.577
4ysjADPCalmodulin-like domain protein kinase/0.490
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.477
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.472
2etm7PYFocal adhesion kinase 12.7.10.20.470
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.470
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.464
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.463
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.462
4gyiADPUncharacterized protein/0.462
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.461
4jrnANPRhoptry kinase family protein/0.461
3c4zADPRhodopsin kinase/0.460
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3nynSGVG protein-coupled receptor kinase 62.7.11.160.458
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.454
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.452
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.451
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.451
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.451
3bqr4RBDeath-associated protein kinase 3/0.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.449
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1unlRRCCyclin-dependent-like kinase 52.7.11.10.448
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.447
3c4wATPRhodopsin kinase/0.447
2ckeIQUDeath-associated protein kinase 2/0.445
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
3e6oA55Nitric oxide synthase, inducible1.14.13.390.444
1v0pPVBCell division control protein 2 homolog2.7.11.220.443
3bu5ATPInsulin receptor2.7.10.10.443
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.443
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.442
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3e6t1A2Nitric oxide synthase, inducible1.14.13.390.441
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.441
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440