Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1y9dFADPyruvate oxidase1.2.3.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1y9dFADPyruvate oxidase1.2.3.31.000
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.495
1poxFADPyruvate oxidase1.2.3.30.478
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.476
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.473
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.469
1n4wFADCholesterol oxidase1.1.3.60.464
2ym2FADPhenylacetone monooxygenase1.14.13.920.464
3b6dFAECholesterol oxidase1.1.3.60.463
4rpgFADUDP-galactopyranose mutase5.4.99.90.463
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.462
1rrmAPRLactaldehyde reductase1.1.1.770.461
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.461
3k4cFADPyranose 2-oxidase/0.461
3tz3B36Acetyl-CoA carboxylase/0.461
4mokFADPyranose 2-oxidase/0.461
1jqdSAHHistamine N-methyltransferase2.1.1.80.460
2gsdNADFormate dehydrogenase/0.460
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.459
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.456
3gyjFADCholesterol oxidase1.1.3.60.456
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.456
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.455
1kt3RTLRetinol-binding protein 4/0.455
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.455
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.455
2f1kNAPPrephenate dehydrogenase/0.454
2q4bNAPUncharacterized protein At5g02240/0.453
3hdyFADUDP-galactopyranose mutase/0.453
4cpdNADAlcohol dehydrogenase/0.453
4u2tFADCholesterol oxidase1.1.3.60.453
1wuuANPGalactokinase2.7.1.60.452
2z6dFMNPhototropin-22.7.11.10.452
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.452
2rlcCHDCholoylglycine hydrolase3.5.1.240.451
2vbdV10Isopenicillin N synthase1.21.3.10.451
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.451
4xwrFADCholesterol oxidase1.1.3.60.451
3cnjFADCholesterol oxidase1.1.3.60.450
3lshFADPyranose 2-oxidase/0.450
4isk1JYThymidylate synthase/0.450
5d4uSAMUncharacterized protein MJ0489/0.450
1n1pFADCholesterol oxidase1.1.3.60.449
1xq6NAPUncharacterized protein At5g02240/0.449
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.449
4b8wNAPGDP-L-fucose synthase1.1.1.2710.449
4xxgFADCholesterol oxidase1.1.3.60.449
5dozNDPJamJ/0.449
2po7CHDFerrochelatase, mitochondrial4.99.1.10.448
3mn6ATPActin-5C/0.448
3wv9FEGHmd co-occurring protein HcgE/0.448
4jqh1MFAlr2278 protein/0.448
5br4NADLactaldehyde reductase1.1.1.770.448
1geeNADGlucose 1-dehydrogenase1.1.1.470.447
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3ak4NADNADH-dependent quinuclidinone reductase/0.447
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.447
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.447
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
2ejvNADL-threonine 3-dehydrogenase/0.446
2gewFADCholesterol oxidase1.1.3.60.446
2oo5TXDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
2rg6287Mitogen-activated protein kinase 14/0.446
3jskAHZThiamine thiazole synthase/0.446
1zemNADXylitol dehydrogenase/0.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
2yxuATPPyridoxal kinase2.7.1.350.445
3c212BADNA integrity scanning protein DisA/0.445
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.445
4pd6URINucleoside permease/0.445
1e3lNADAlcohol dehydrogenase 41.1.1.10.444
1osvCHCBile acid receptor/0.444
2bu9HFVIsopenicillin N synthase1.21.3.10.444
3m13FADMonomeric sarcosine oxidase1.5.3.10.444
3wdsNADNADH-dependent quinuclidinone reductase/0.444
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.444
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2bm9SAMCephalosporin hydroxylase CmcI/0.443
2bsmBSMHeat shock protein HSP 90-alpha/0.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3u4cNDPNADPH-dependent reductase BacG/0.443
4do30LAFatty-acid amide hydrolase 13.5.1.990.443
4xyeNADFormate dehydrogenase/0.443
1dvrATFAdenylate kinase/0.442
2y02WHJBeta-1 adrenergic receptor/0.442
2ylzFADPhenylacetone monooxygenase1.14.13.920.442
3aebFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.442
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3lu8IQXSerum albumin/0.442
3ox4NADAlcohol dehydrogenase 21.1.1.10.442
3wmxNADNAD dependent epimerase/dehydratase/0.442
4fhf0TTSpore photoproduct lyase/0.442
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.442
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2pd8FADVivid PAS protein VVD/0.441
2yvlSAMtRNA (adenine(58)-N(1))-methyltransferase TrmI/0.441
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.441
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.441
3stxBKAMethylketone synthase I/0.441
1hldNADAlcohol dehydrogenase E chain1.1.1.10.440
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.440
2trtTACTetracycline repressor protein class D/0.440
3b70NAPEnoyl reductase LovC10.440
3lsmSFDPyranose 2-oxidase/0.440
3qvtNAIMyo-inositol-1-phosphate synthase (Ino1)/0.440
3tqaNDPDihydrofolate reductase/0.440