sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 1.000 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.539 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.472 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.461 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.459 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.458 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.456 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.449 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.449 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.442 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.441 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.441 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.440 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.440 |