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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1uvsI11Prothrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1uvsI11Prothrombin3.4.21.51.000
2v3oI26Prothrombin3.4.21.50.627
4ax9N5NProthrombin3.4.21.50.597
2bvs2CEProthrombin3.4.21.50.586
2jh5895Prothrombin3.4.21.50.586
4lxb7R9Prothrombin3.4.21.50.585
2zi224UProthrombin3.4.21.50.580
4ayy9MXProthrombin3.4.21.50.575
1ypgUIRProthrombin3.4.21.50.565
2gdeSN3Prothrombin3.4.21.50.562
1d6w00RProthrombin3.4.21.50.561
1d4pBPPProthrombin3.4.21.50.559
2zhe13UProthrombin3.4.21.50.559
2zfq45UProthrombin3.4.21.50.557
1ypjUIBProthrombin3.4.21.50.556
1ypkCCRProthrombin3.4.21.50.556
2zfr46UProthrombin3.4.21.50.552
2zhf49UProthrombin3.4.21.50.552
3dhk23UProthrombin3.4.21.50.549
1sb1165Prothrombin3.4.21.50.548
3c1kT15Prothrombin3.4.21.50.548
1nm6L86Prothrombin3.4.21.50.547
1d3dBZTProthrombin3.4.21.50.545
1t4u81AProthrombin3.4.21.50.545
1c4uIH1Prothrombin3.4.21.50.544
1d9i00PProthrombin3.4.21.50.544
1t4v14AProthrombin3.4.21.50.541
4ayv9MQProthrombin3.4.21.50.539
1ypmRA4Prothrombin3.4.21.50.537
2r2mI50Prothrombin3.4.21.50.537
2zda32UProthrombin3.4.21.50.537
2ziq26UProthrombin3.4.21.50.535
4loy6XSProthrombin3.4.21.50.535
1mu8CDBProthrombin3.4.21.50.533
4az29MUProthrombin3.4.21.50.532
1gj4132Prothrombin3.4.21.50.531
1riwOSCProthrombin3.4.21.50.530
1xm1GAHProthrombin3.4.21.50.527
1oytFSNProthrombin3.4.21.50.526
2zc922UProthrombin3.4.21.50.526
1k21IGNProthrombin3.4.21.50.523
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.523
1c4vIH2Prothrombin3.4.21.50.521
1ta6177Prothrombin3.4.21.50.520
3egkM18Prothrombin3.4.21.50.519
1o5gCR9Prothrombin3.4.21.50.517
1c4yIH3Prothrombin3.4.21.50.516
1gj5130Prothrombin3.4.21.50.512
2a2xNA9Prothrombin3.4.21.50.511
2zg050UProthrombin3.4.21.50.509
1o2g696Prothrombin3.4.21.50.508
1a4wQWEProthrombin3.4.21.50.507
1mueCDDProthrombin3.4.21.50.507
1zgi382Prothrombin3.4.21.50.507
3qwc98PProthrombin3.4.21.50.507
2uuk897Prothrombin3.4.21.50.506
2zgx29UProthrombin3.4.21.50.504
2jh0701Prothrombin3.4.21.50.503
4hfp15UProthrombin3.4.21.50.501
1z71L17Prothrombin3.4.21.50.499
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.498
1vzqSHYProthrombin3.4.21.50.497
4rn615UProthrombin3.4.21.50.496
2zhq27UProthrombin3.4.21.50.495
2zff53UProthrombin3.4.21.50.494
2zdv37UProthrombin3.4.21.50.493
3eq02TSProthrombin3.4.21.50.493
2anmCDOProthrombin3.4.21.50.492
2zgb21UProthrombin3.4.21.50.492
2znk31UProthrombin3.4.21.50.491
1ae8AZLProthrombin3.4.21.50.489
1ghv120Prothrombin3.4.21.50.486
1zgv501Prothrombin3.4.21.50.484
1afeALZProthrombin3.4.21.50.483
2bdyUNBProthrombin3.4.21.50.483
1c5nESIProthrombin3.4.21.50.479
2zfp19UProthrombin3.4.21.50.479
3biu10UProthrombin3.4.21.50.479
1jwtBLIProthrombin3.4.21.50.476
1bcuPRLProthrombin3.4.21.50.473
3oqkS52Renin3.4.23.150.468
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.464
3biv11UProthrombin3.4.21.50.464
4a802ANMajor pollen allergen Bet v 1-A/0.464
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.462
1o0d163Prothrombin3.4.21.50.462
2iko7IGRenin3.4.23.150.462
2zhw12UProthrombin3.4.21.50.460
3phiNDPShikimate dehydrogenase (NADP(+))/0.460
4e7r0NWProthrombin3.4.21.50.460
4xguADPPutative pachytene checkpoint protein 2/0.459
2cndFADNitrate reductase [NADH]1.7.1.10.458
2rqfJH3Hemolymph juvenile hormone binding protein/0.458
1ktsC24Prothrombin3.4.21.50.456
1zsk421Coagulation factor XI3.4.21.270.453
3qto10PProthrombin3.4.21.50.453
4brgGNPEctonucleoside triphosphate diphosphohydrolase I/0.453
4n3l2FNProthrombin3.4.21.50.453
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.451
2uuj896Prothrombin3.4.21.50.448
2gv8NDPThiol-specific monooxygenase1.14.130.447
2v3hI25Prothrombin3.4.21.50.447
3wagTYDGlycosyltransferase/0.447
4eb7PLPCysteine desulfurase IscS 2/0.447
2cekN8TAcetylcholinesterase3.1.1.70.446
4a862ANMajor pollen allergen Bet v 1-A/0.445
1owe675Urokinase-type plasminogen activator3.4.21.730.444
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.443
2vhqATPNTPase P4/0.442
2vkeTACTetracycline repressor protein class D/0.442
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.442
4esoNAPPutative oxidoreductase/0.441
2v5aLZLBiotin carboxylase6.3.4.140.440
4zweDGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440