sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1sdm | ADP | Kinesin heavy chain-like protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 1.000 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.488 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.471 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.470 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.467 | |
| 3gob | HXX | DdmC | / | 0.466 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.463 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 3b9l | AZZ | Serum albumin | / | 0.463 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.462 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.460 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.457 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.456 | |
| 4biz | ADP | Sensor histidine kinase CpxA | / | 0.455 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.454 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.451 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.451 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3v2u | ATP | Protein GAL3 | / | 0.451 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.451 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.450 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.449 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.448 | |
| 4xr9 | NAD | CalS8 | / | 0.448 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.446 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2j09 | FMN | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.446 | |
| 3ncr | ADP | Nitrogen regulatory protein P-II (GlnB-2) | / | 0.446 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2bxm | IMN | Serum albumin | / | 0.445 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 3eks | CY9 | Actin-5C | / | 0.445 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 4alx | IZN | Acetylcholine-binding protein | / | 0.445 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3uf6 | COD | Lmo1369 protein | / | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.442 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.442 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.442 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.442 | |
| 1e2n | RCA | Thymidine kinase | / | 0.441 | |
| 3da1 | FAD | Glycerol-3-phosphate dehydrogenase | / | 0.441 | |
| 3jzm | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.441 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.441 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4hxy | NDP | Plm1 | / | 0.441 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4jic | FMN | GTN Reductase | / | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.440 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.440 |