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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s9dAFBCytohesin-2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s9dAFBCytohesin-2/1.000
1s9dAFBADP-ribosylation factor 1/1.000
1r8qAFBCytohesin-2/0.584
1r8qAFBADP-ribosylation factor 1/0.584
1re0AFBADP-ribosylation factor 1/0.522
1re0AFBARF guanine-nucleotide exchange factor 1/0.522
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.476
4ktf1TMCytochrome P450/0.474
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.470
5bp9SAHPutative methyltransferase protein/0.467
5kf2ACOPredicted acetyltransferase/0.467
3a1l2CCCytochrome P450/0.466
5kf9ACOPredicted acetyltransferase/0.465
5jtbZMAAdenosine receptor A2a/0.465
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.463
5kf8ACOPredicted acetyltransferase/0.463
4b4w9L9Bifunctional protein FolD/0.460
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.458
1u1d181Uridine phosphorylase2.4.2.30.457
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1b87ACOAac(6')-Ii protein/0.455
4iaq2GM5-hydroxytryptamine receptor 1B/0.455
7catNDPCatalase1.11.1.60.454
2ewaSB2Mitogen-activated protein kinase 14/0.453
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.453
4iarERM5-hydroxytryptamine receptor 1B/0.453
5k2cZMAAdenosine receptor A2a/0.453
2geuCOKPantothenate kinase2.7.1.330.452
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.451
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
5k2bZMAAdenosine receptor A2a/0.451
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.450
4ktkKTKCytochrome P450/0.450
8catNDPCatalase1.11.1.60.450
5k2aZMAAdenosine receptor A2a/0.450
1dgfNDPCatalase1.11.1.60.449
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.449
3g5hYTTMycocyclosin synthase1.14.21.90.449
5kgjACOPredicted acetyltransferase/0.449
2f3815MAldo-keto reductase family 1 member C3/0.448
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4j6cSTRCytochrome P450 monooxygenase/0.448
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
5dp2NAPCurF/0.447
5kf1ACOPredicted acetyltransferase/0.447
5kghACOPredicted acetyltransferase/0.447
3emlZMAAdenosine receptor A2a/0.447
1v7aFRCAdenosine deaminase3.5.4.40.446
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.445
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.445
2yczI32Beta-1 adrenergic receptor/0.445
2w4qCBWProstaglandin reductase 21.3.1.480.444
1dlrMXADihydrofolate reductase1.5.1.30.443
2zb8IMNProstaglandin reductase 21.3.1.480.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.443
1kceCB3Thymidylate synthase/0.442
4ips1G4Mycocyclosin synthase1.14.21.90.442
4ktl1CQCytochrome P450/0.442
5fm7ADPRuvB-like helicase/0.442
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3s7a684Dihydrofolate reductase1.5.1.30.441
4b4vL34Bifunctional protein FolD/0.441
4ia1BIVVitamin D3 receptor A/0.441
4qohSTLRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
2rh1CAUBeta-2 adrenergic receptor/0.441
1db1VDXVitamin D3 receptor/0.440
1fmlRTLRetinol dehydratase/0.440
1jtqLY3Thymidylate synthase/0.440
2oreSAHDNA adenine methylase2.1.1.720.440
3cr0809Wee1-like protein kinase2.7.10.20.440
3p99LNPLanosterol 14-alpha-demethylase/0.440
4at0FADPossible succinate dehydrogenase/0.440
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4g48PZBMycocyclosin synthase1.14.21.90.440
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.440
4zvmDM2Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440