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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1m7aMQUDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1m7aMQUDihydrofolate reductase1.5.1.31.000
1ia2TQ4Dihydrofolate reductase1.5.1.30.744
1aoeGW3Dihydrofolate reductase1.5.1.30.735
1m78CLZDihydrofolate reductase1.5.1.30.701
4h9614QDihydrofolate reductase1.5.1.30.637
3qlwN22Dihydrofolate reductase1.5.1.30.632
4h9753SDihydrofolate reductase1.5.1.30.606
3qlrQLRDihydrofolate reductase1.5.1.30.604
3qls55VDihydrofolate reductase1.5.1.30.601
4ixeIXEDihydrofolate reductase1.5.1.30.598
1m79MQ1Dihydrofolate reductase1.5.1.30.595
1ia1TQ3Dihydrofolate reductase1.5.1.30.594
1klkPMDDihydrofolate reductase1.5.1.30.593
4h9506UDihydrofolate reductase1.5.1.30.584
3cseN22Uncharacterized protein/0.583
3eel53TUncharacterized protein/0.577
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.574
3qlzQLZUncharacterized protein/0.568
1rx3MTXDihydrofolate reductase1.5.1.30.565
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.564
3eek53SUncharacterized protein/0.559
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.559
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.558
4h9814QUncharacterized protein/0.556
1dg5TOPDihydrofolate reductase1.5.1.30.551
3qly55VUncharacterized protein/0.545
1ia4TQ6Dihydrofolate reductase1.5.1.30.543
3ia4MTXDihydrofolate reductase/0.538
3td8D2RDihydrofolate reductase1.5.1.30.538
1dajMOTDihydrofolate reductase1.5.1.30.536
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.535
4cd2FOLDihydrofolate reductase1.5.1.30.535
2fziDH3Dihydrofolate reductase1.5.1.30.534
3eej53RUncharacterized protein/0.532
4xe606UDihydrofolate reductase1.5.1.30.532
2w3vTOPDihydrofolate reductase/0.531
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.530
3sh25DRDihydrofolate reductase1.5.1.30.530
3cd2MTXDihydrofolate reductase1.5.1.30.529
3eem53VUncharacterized protein/0.529
3jwm5WBDihydrofolate reductase/0.529
4m2xTMQDihydrofolate reductase1.5.1.30.527
3jwcEKBDihydrofolate reductase/0.526
1ia3TQ5Dihydrofolate reductase1.5.1.30.525
3qlxQLRUncharacterized protein/0.525
3sa16DRDihydrofolate reductase/0.523
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.522
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.522
3fywXCFDihydrofolate reductase1.5.1.30.521
2fzhDH1Dihydrofolate reductase1.5.1.30.520
1cd2FOLDihydrofolate reductase1.5.1.30.518
1vj3TABDihydrofolate reductase1.5.1.30.515
4p66MTXDihydrofolate reductase/0.512
1df7MTXDihydrofolate reductase1.5.1.30.510
2drcMTXDihydrofolate reductase1.5.1.30.510
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.510
3dfrMTXDihydrofolate reductase1.5.1.30.507
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.506
3jw5TOPDihydrofolate reductase/0.506
1tdrMTXDihydrofolate reductase1.5.1.30.505
3och2MXDihydrofolate reductase1.5.1.30.505
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.503
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.503
1ddsMTXDihydrofolate reductase1.5.1.30.500
1draMTXDihydrofolate reductase1.5.1.30.499
3drcMTXDihydrofolate reductase1.5.1.30.499
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.499
1drbMTXDihydrofolate reductase1.5.1.30.498
3dauMTXDihydrofolate reductase1.5.1.30.498
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.498
1ly3COGDihydrofolate reductase1.5.1.30.497
4g8zTOPDihydrofolate reductase1.5.1.30.496
4ixfIXFDihydrofolate reductase1.5.1.30.496
3sa27DRDihydrofolate reductase/0.495
3fy9XCFDihydrofolate reductase1.5.1.30.494
4j6cSTRCytochrome P450 monooxygenase/0.494
2zzaFOLDihydrofolate reductase/0.492
4nx6FOLDihydrofolate reductase1.5.1.30.492
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.491
1hfqMOTDihydrofolate reductase1.5.1.30.490
2cd2FOLDihydrofolate reductase1.5.1.30.490
1dg7WRBDihydrofolate reductase1.5.1.30.488
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
3freTOPDihydrofolate reductase1.5.1.30.488
3frdDHFDihydrofolate reductase1.5.1.30.485
1dhjMTXDihydrofolate reductase1.5.1.30.483
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.483
3d80Q22Dihydrofolate reductase1.5.1.30.483
3tqbFOLDihydrofolate reductase/0.483
4x5gFOLDihydrofolate reductase1.5.1.30.483
1ddrMTXDihydrofolate reductase1.5.1.30.482
4fgg0U5Dihydrofolate reductase1.5.1.30.482
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.479
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.479
4j6dTESCytochrome P450 monooxygenase/0.479
1rb3MTXDihydrofolate reductase1.5.1.30.478
7dfrFOLDihydrofolate reductase1.5.1.30.478
3tq9MTXDihydrofolate reductase/0.477
4ia1BIVVitamin D3 receptor A/0.477
4ixgIXGDihydrofolate reductase1.5.1.30.477
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.477
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.475
4kbn25UDihydrofolate reductase1.5.1.30.475
4x5fFOLDihydrofolate reductase1.5.1.30.475
5cccDDFDihydrofolate reductase1.5.1.30.475
1jolFFODihydrofolate reductase1.5.1.30.473
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.473
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.473
1re7FOLDihydrofolate reductase1.5.1.30.472
4ej1FOLDihydrofolate reductase1.5.1.30.472
4j6bPLOCytochrome P450 monooxygenase/0.472
1ek2CDUBifunctional epoxide hydrolase 2/0.471
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.471
3sai9DRDihydrofolate reductase/0.471
4ib4ERM5-hydroxytryptamine receptor 2B/0.470
3ix9MTXDihydrofolate reductase1.5.1.30.469
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.469
4fgh0U6Dihydrofolate reductase1.5.1.30.469
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.469
4o761M3Bromodomain-containing protein 4/0.469
2d0kFOLDihydrofolate reductase1.5.1.30.468
3cv9VDXVitamin D3 dihydroxylase/0.468
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3mdvCL6Cholesterol 24-hydroxylase/0.468
4dfrMTXDihydrofolate reductase1.5.1.30.468
4nx7FOLDihydrofolate reductase1.5.1.30.468
1og5SWFCytochrome P450 2C9/0.467
3k47D09Dihydrofolate reductase1.5.1.30.467
3fyvXCFDihydrofolate reductase1.5.1.30.466
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.466
2fzjDH3Dihydrofolate reductase1.5.1.30.465
4nc3ERM5-hydroxytryptamine receptor 2B/0.465
1rf7DHFDihydrofolate reductase1.5.1.30.464
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
1e26GPBDihydrofolate reductase1.5.1.30.463
1hfpMOTDihydrofolate reductase1.5.1.30.463
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.463
2ph5NADHomospermidine synthase/0.463
4ia7BIVVitamin D3 receptor A/0.463
4nb6444Nuclear receptor ROR-gamma/0.463
3oafOAGDihydrofolate reductase1.5.1.30.462
3sruQ26Dihydrofolate reductase1.5.1.30.462
4g1z0VPVitamin D3 receptor A/0.462
4x5jFOLDihydrofolate reductase1.5.1.30.462
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
2zbaZBATrichothecene 3-O-acetyltransferase/0.461
2ze2T27Gag-Pol polyprotein2.7.7.490.461
3srwQ27Dihydrofolate reductase1.5.1.30.461
4jbtASDCytochrome P450 monooxygenase/0.461
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.460
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3tmz06XCytochrome P450 2B41.14.14.10.460
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.460
3sgy06WDihydrofolate reductase1.5.1.30.459
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
5hi6MTXDihydrofolate reductase/0.459
1rd7FOLDihydrofolate reductase1.5.1.30.458
1s3yTQTDihydrofolate reductase1.5.1.30.458
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
1dyjDDFDihydrofolate reductase1.5.1.30.457
1ysx4EBSerum albumin/0.457
3abaFLICytochrome P450/0.456
1ohkCOPDihydrofolate reductase1.5.1.30.455
2hb8MVDVitamin D3 receptor/0.455
2vn0TDZCytochrome P450 2C8/0.455
3tdaPN0Cytochrome P450 2D6/0.455
4iw8KN3Estrogen receptor/0.455
4jlj1NMDeoxycytidine kinase2.7.1.740.455
1vrwNAIEnoyl-ACP reductase/0.454
4m6l21VDihydrofolate reductase1.5.1.30.454
1q5dEPBEpothilone C/D epoxidase1.140.452
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
3fraI2HDihydrofolate reductase1.5.1.30.452
3fwjCAMCamphor 5-monooxygenase1.14.15.10.452
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.452
4kak06UDihydrofolate reductase1.5.1.30.452
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
3frfXCFDihydrofolate reductase1.5.1.30.451
3lu8IQXSerum albumin/0.451
3nj0PYVAbscisic acid receptor PYL2/0.451
2w3wVG9Dihydrofolate reductase/0.450
3adaNADSubunit alpha of sarocosine oxidase/0.450
3tm5SFGUncharacterized protein/0.450
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
1ie9VDXVitamin D3 receptor/0.449
1rb2FOLDihydrofolate reductase1.5.1.30.449
4iarERM5-hydroxytryptamine receptor 1B/0.449
1dyiFOLDihydrofolate reductase1.5.1.30.448
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.448
3fl8RARDihydrofolate reductase/0.448
3l3rOAGDihydrofolate reductase1.5.1.30.448
3lnbCOAN-acetyltransferase family protein/0.448
3sqyQ11Dihydrofolate reductase1.5.1.30.448
4p6wMOFGlucocorticoid receptor/0.448
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1t88CAMCamphor 5-monooxygenase1.14.15.10.447
2hasC3OVitamin D3 receptor/0.447
2vqoTFGHistone deacetylase 43.5.1.980.447
3l8sBFFMitogen-activated protein kinase 14/0.447
4fhi0S4Vitamin D3 receptor A/0.447
4k9yK9YFocal adhesion kinase 12.7.10.20.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
1l2jETCEstrogen receptor beta/0.446
3p99LNPLanosterol 14-alpha-demethylase/0.446
3ql3FOLDihydrofolate reductase1.5.1.30.446
3ua506XCytochrome P450 2B61.14.130.446
3vt65YIVitamin D3 receptor/0.445
1pkfEPDEpothilone C/D epoxidase1.140.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3srrQ20Dihydrofolate reductase1.5.1.30.444
3vrwYS5Vitamin D3 receptor/0.444
3vt5YI2Vitamin D3 receptor/0.444
4elb34SDihydrofolate reductase/0.444
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.444
4p68MTXDihydrofolate reductase/0.444
4x5iFOLDihydrofolate reductase1.5.1.30.444
1uzwCDHIsopenicillin N synthase1.21.3.10.443
2zl9VDAVitamin D3 receptor/0.443
3antS82Bifunctional epoxide hydrolase 23.3.2.100.443
3qlhT27Gag-Pol polyprotein2.7.7.490.443
3tdl11DSerum albumin/0.443
1dhiMTXDihydrofolate reductase1.5.1.30.442
2hb7O1CVitamin D3 receptor/0.442
3e6oA55Nitric oxide synthase, inducible1.14.13.390.442
3gwfFADCyclohexanone monooxygenase/0.442
4r21STRCytochrome P450 family 17 polypeptide 2/0.442
1fm4DXCMajor pollen allergen Bet v 1-L/0.441
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3kpzZNEVitamin D3 receptor/0.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
1dhfFOLDihydrofolate reductase1.5.1.30.440
1ly4COQDihydrofolate reductase1.5.1.30.440
2dhfDZFDihydrofolate reductase1.5.1.30.440
2y30SM8Putative repressor SimReg2/0.440
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.440
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.440
4ia2BIVVitamin D3 receptor A/0.440